Multivitamin supplementation improves nutritional status and bone quality in aged care residents

Grieger, J. A., Nowson, C. A., Jarman, H. F., Malon, R. and Ackland, L. M. 2009, Multivitamin supplementation improves nutritional status and bone quality in aged care residents, European journal of clinical nutrition, vol. 63, no. 4, pp. 558-565.

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Title Multivitamin supplementation improves nutritional status and bone quality in aged care residents
Author(s) Grieger, J. A.
Nowson, C. A.
Jarman, H. F.
Malon, R.
Ackland, L. M.
Journal name European journal of clinical nutrition
Volume number 63
Issue number 4
Start page 558
End page 565
Total pages 8
Publisher Nature Publishing Group
Place of publication Basingstoke, England
Publication date 2009-04
ISSN 0954-3007
1476-5640
Keyword(s) multivitamin
residential care
25(OH)D
heel ultrasound
Summary Objectives: To assess the effectiveness of a multivitamin (MV) tablet on nutritional status, quantitative heel ultrasound (QUS), mobility, muscle strength and falls. The design comprised two groups matched on mobility levels, randomized to receive a daily MV or placebo (P) tablet for 6 months. The setting was an Australian residential care facility.

Subjects: A total of 92 aged care residents. Serum micronutrients, body weight, QUS, rate of falls, hand grip strength, and the timed up and go test were assessed at baseline and 6 months.

Results: A total of 49 participants consumed a MV and 43, a matched P for 6 months. There was a greater increase in the MV vs P group for serum 25(OH)D (mean differencestandard error, 33.42.6 nmol l-1), folate (13.42.8 nmol l-1), and vitamin B12 (178.040.3 pmol l-1) (all P<0.001). Adequate 25(OH)D concentrations (50 nmol l-1) were found among 77% of participants in the MV group vs 10% taking P (P<0.001). Adjusting for baseline levels, the increase in QUS was greater in the MV vs P group (3.02.0 dB MHz-1 vs -2.92.1 dB MHz-1, respectively, P=0.041). There was a trend towards a 63% lower mean number of falls in the MV vs P group (0.30.1 falls vs 0.80.3 falls, P=0.078).

Conclusions: MV supplementation raised serum vitamin B12 and folate concentrations and increased serum 25(OH)D, which was accompanied by an apparent positive effect on bone density. We also found a trend towards a reduction in falls and this could contribute to a reduction in fractures.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
HERDC collection year 2009
Copyright notice ©2009, Nature Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30020095

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