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Food patterns associated with blood lipids are predictive of coronary heart disease : the Whitehall II study

McNaughton, Sarah, Mishra, Gita and Brunner, Eric 2009, Food patterns associated with blood lipids are predictive of coronary heart disease : the Whitehall II study, British journal of nutrition, vol. 102, no. 4, pp. 619-624.

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Title Food patterns associated with blood lipids are predictive of coronary heart disease : the Whitehall II study
Author(s) McNaughton, Sarah
Mishra, Gita
Brunner, Eric
Journal name British journal of nutrition
Volume number 102
Issue number 4
Start page 619
End page 624
Total pages 6
Publisher Cambridge University Press
Place of publication [Cambridge, England]
Publication date 2009-08-28
ISSN 0007-1145
1475-2662
Keyword(s) lipids
cardiovascular disease
blood
Summary Analysis of the epidemiological effects of overall dietary patterns offers an alternative approach to the investigation of the role of diet in CHD. We analysed the role of blood lipid-related dietary patterns using a two-step method to confirm the prospective association of dietary pattern with incident CHD. Analysis is based on 7314 participants of the Whitehall II study. Dietary intake was measured using a 127-item FFQ. Reduced rank regression (RRR) was used to derive dietary pattern scores using baseline serum total and HDL-cholesterol, and TAG levels as dependent variables. Cox proportional hazard regression was used to confirm the association between dietary patterns and incident CHD (n 243) over 15 years of follow-up. Increased CHD risk (hazard ratio (HR) for top quartile: 2·01 (95 % CI 1·41, 2·85) adjusted for age, sex, ethnicity and energy misreporting) was observed with a diet characterised by high consumption of white bread, fried potatoes, sugar in tea and coffee, burgers and sausages, soft drinks, and low consumption of French dressing and vegetables. The diet-CHD relationship was attenuated after adjustment for employment grade and health behaviours (HR for top quartile: 1·81; 95 % CI 1·26, 2·62), and further adjustment for blood pressure and BMI (HR for top quartile: 1·57; 95 % CI 1·08, 2·27). Dietary patterns are associated with serum lipids and predict CHD risk after adjustment for confounders. RRR identifies dietary patterns using prior knowledge and focuses on the pathways through which diet may influence disease. The present study adds to the evidence that diet is an important risk factor for CHD.
Language eng
Field of Research 111706 Epidemiology
Socio Economic Objective 920401 Behaviour and Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2009, Cambridge University Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30020249

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Created: Thu, 01 Oct 2009, 13:53:10 EST by Deborah Wittahatchy

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.