Statphylococcus aureus bacteraemia : a major cause of mortaility in Australia and New Zealand

Turnidge, John D., Kotsanas, Despina, Muckoff, Wendy, Roberts, Sally, Bennett, Catherine M., Nimmo, Graeme R., Coombs, Geoffrey W., Murray, Ronan J., Howden, Benjamin, Johnson, Paul D. R. and Dowling, Kate 2009, Statphylococcus aureus bacteraemia : a major cause of mortaility in Australia and New Zealand, Medical journal of Australia, vol. 191, no. 7, pp. 368-373.

Attached Files
Name Description MIMEType Size Downloads

Title Statphylococcus aureus bacteraemia : a major cause of mortaility in Australia and New Zealand
Author(s) Turnidge, John D.
Kotsanas, Despina
Muckoff, Wendy
Roberts, Sally
Bennett, Catherine M.ORCID iD for Bennett, Catherine M.
Nimmo, Graeme R.
Coombs, Geoffrey W.
Murray, Ronan J.
Howden, Benjamin
Johnson, Paul D. R.
Dowling, Kate
Journal name Medical journal of Australia
Volume number 191
Issue number 7
Start page 368
End page 373
Total pages 6
Publisher Australasian Medical Pub. Co.
Place of publication Sydney, N.S.W.
Publication date 2009-10-05
ISSN 0025-729X
Summary Objective : To document the types of, and mortality from, Staphylococcus aureus bacteraemia in Australia and New Zealand, and determine factors associated with mortality.

Design and setting : Prospective observational study in 27 independent or hospital pathology laboratories in Australia (24) and New Zealand (3), employing a web-based database to prospectively record demographic features, selected risk factors, principal antibiotic treatment and mortality data on all patients with positive blood cultures for S. aureus from June 2007 to May 2008.

Main outcome measure : 30-day all-cause mortality.

Results : 1994 episodes of S. aureus bacteraemia were identified, and complete 30-day follow-up data were available for 1865. Most episodes had their onset in the community (60.8%; 95% CI, 58.7%–63.0%). Methicillin-resistant S. aureus (MRSA) caused 450 episodes (24.1%; 95% CI, 22.2%–25.9%), and 123 of these (27.3%) had a susceptibility profile consistent with community-associated MRSA. All-cause mortality at 30 days was 20.6% (95% CI, 18.8%–22.5%). On univariate analysis, increased mortality was significantly associated with older age, European ethnicity, MRSA infection, infections not originating from a medical device, sepsis syndrome, pneumonia/empyema, and treatment with a glycopeptide or other non-β-lactam antibiotic. On multivariable analysis, independent predictors of mortality were age, sepsis syndrome, pneumonia/empyema, device-associated infection with a secondary focus, left-sided endocarditis, and treatment with a glycopeptide such as vancomycin, but not MRSA infection.

Conclusions : S. aureus bacteraemia is a common infection in both the community and hospitals in Australia and New Zealand, and is associated with appreciable mortality. Invasive MRSA infection may be more life-threatening, partly because of the inferior efficacy of the standard treatment, vancomycin. National web-based surveillance of S. aureus bacteraemia and its outcomes is not only important but also easily achievable.
Language eng
Field of Research 111706 Epidemiology
Socio Economic Objective 920204 Evaluation of Health Outcomes
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2009
Copyright notice ©2009, MJA
Persistent URL

Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 141 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 981 Abstract Views, 3 File Downloads  -  Detailed Statistics
Created: Fri, 16 Oct 2009, 14:16:25 EST by Sally Morrigan

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact