The relationship between monocarboxylate transporters 1 and 4 expression in skeletal muscle and endurance performance in athletes

Bentley, David J., Roels, Belle, Thomas, Claire, Ives, Robert, Mercier, Jacques, Millet, Gregoire and Cameron-Smith, David 2009, The relationship between monocarboxylate transporters 1 and 4 expression in skeletal muscle and endurance performance in athletes, European journal of applied physiology, vol. 106, no. 3, pp. 465-471.

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Title The relationship between monocarboxylate transporters 1 and 4 expression in skeletal muscle and endurance performance in athletes
Author(s) Bentley, David J.
Roels, Belle
Thomas, Claire
Ives, Robert
Mercier, Jacques
Millet, Gregoire
Cameron-Smith, David
Journal name European journal of applied physiology
Volume number 106
Issue number 3
Start page 465
End page 471
Publisher Springer Berlin
Place of publication Berlin, Germany
Publication date 2009-06
ISSN 1439-6319
1439-6327
Keyword(s) aerobic
cycling
power
regulation
correlation
Summary The purpose of this study was to examine the relationship between skeletal muscle monocarboxylate transporters 1 and 4 (MCT1 and MCT4) expression, skeletal muscle oxidative capacity and endurance performance in trained cyclists. Ten well-trained cyclists (mean ± SD; age 24.4 ± 2.8 years, body mass 73.2 ± 8.3 kg, VO2max 58 ± 7 ml kg−1 min−1) completed three endurance performance tasks [incremental exercise test to exhaustion, 2 and 10 min time trial (TT)]. In addition, a muscle biopsy sample from the vastus lateralis muscle was analysed for MCT1 and MCT4 expression levels together with the activity of citrate synthase (CS) and 3-hydroxyacyl-CoA dehydrogenase (HAD). There was a tendency for VO2max and peak power output obtained in the incremental exercise test to be correlated with MCT1 (r = −0.71 to −0.74; P < 0.06), but not MCT4. The average power output (P average) in the 2 min TT was significantly correlated with MCT4 (r = −0.74; P < 0.05) and HAD (r = −0.92; P < 0.01). The P average in the 10 min TT was only correlated with CS activity (r = 0.68; P < 0.05). These results indicate the relationship between MCT1 and MCT4 as well as cycle TT performance may be influenced by the length and intensity of the task.
Language eng
Field of Research 110602 Exercise Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2009
Copyright notice ©2009, Springer-Verlag
Persistent URL http://hdl.handle.net/10536/DRO/DU:30020653

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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