Apparent in vivo Δ-6 desaturase activity, efficiency, and affinity are affected by total dietary C18 PUFA in the freshwater fish Murray cod

Francis, David, Peters, Daniel and Turchini, Giovanni.M. 2009, Apparent in vivo Δ-6 desaturase activity, efficiency, and affinity are affected by total dietary C18 PUFA in the freshwater fish Murray cod, Journal of agricultural and food chemistry, vol. 57, no. 10, pp. 4381-4390.

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Title Apparent in vivo Δ-6 desaturase activity, efficiency, and affinity are affected by total dietary C18 PUFA in the freshwater fish Murray cod
Formatted title Apparent in vivo Δ-6 desaturase activity, efficiency, and affinity are affected by total dietary C18 PUFA in the freshwater fish Murray cod
Author(s) Francis, David
Peters, Daniel
Turchini, Giovanni.M.
Journal name Journal of agricultural and food chemistry
Volume number 57
Issue number 10
Start page 4381
End page 4390
Total pages 10
Publisher American Chemical Society
Place of publication United States
Publication date 2009-05-27
ISSN 0021-8561
1520-5118
Keyword(s) Maccullochella peeli peeli
enzyme affinity
Δ-6 desaturase
fatty acid
linoleic acid
α-linolenic acid
Summary Dietary fatty acids are known to modulate fatty acid metabolism in fish. However, the innate capability of fish to bioconvert short chain fatty acids to health promoting long chain fatty acids (LCPUFA) is insufficient to compensate for a reduced dietary intake. While many studies have focused on the dietary regulation of the fatty acid bioconversion pathways, there is little known regarding the effects of the dietary levels of C18 polyunsaturated fatty acids (PUFA) on fatty acid metabolism. Here, we show a greater degree of apparent enzyme activity (Δ-6 desaturase) in fish fed a diet with higher amounts of dietary C18 PUFA. In particular, fish receiving high amounts of dietary C18 PUFA had a greater amount of Δ-6 desaturase activity acting on 18:3n-3 than 18:2n-6. However, with the gradual reduction of dietary C18 PUFA there was a shift in substrate preference of Δ-6 desaturase from 18:3n-3 to 18:2n-6. This information will provide valuable insight for the implementation of low fish oil diets, which permit the maintenance of n-3 LCPUFA levels in farmed Murray cod.
Language eng
Field of Research 070401 Aquaculture
Socio Economic Objective 830506 Unprocessed or Minimally Processed Fish
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2009
Copyright notice ©2009, American Chemical Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30020782

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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