Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance. The Australian Diabetes, Obesity and Lifestyle Study (AusDiab)

Barr, Elizabeth L. M., Zimmet, Paul Z., Welborn, Timothy A., Jolley, Damien, Magliano, Dianna J., Dunstan, David W., Cameron, Adrian J., Dwyer, Terry, Taylor, Hugh R., Tonkin, Andrew M., Wong, Tien Y., McNeil, John and Shaw, Jonathan E. 2007, Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance. The Australian Diabetes, Obesity and Lifestyle Study (AusDiab), Circulation, vol. 116, no. 2, pp. 151-157.

Attached Files
Name Description MIMEType Size Downloads

Title Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance. The Australian Diabetes, Obesity and Lifestyle Study (AusDiab)
Author(s) Barr, Elizabeth L. M.
Zimmet, Paul Z.
Welborn, Timothy A.
Jolley, Damien
Magliano, Dianna J.
Dunstan, David W.
Cameron, Adrian J.
Dwyer, Terry
Taylor, Hugh R.
Tonkin, Andrew M.
Wong, Tien Y.
McNeil, John
Shaw, Jonathan E.
Journal name Circulation
Volume number 116
Issue number 2
Start page 151
End page 157
Publisher Lippincott, Williams & Wilkins
Place of publication [Baltimore, Md.]
Publication date 2007-07-10
ISSN 0009-7322
1524-4539
Keyword(s) epidemiology
diabetes mellitus
mortality
risk factors
cardiovascular diseases
risk fact
Summary Background--Diabetes mellitus increases the risk of cardiovascular disease (CVD) and all-cause mortality. The relationship between milder elevations of blood glucose and mortality is less clear. This study investigated whether impaired fasting glucose and impaired glucose tolerance, as well as diabetes mellitus, increase the risk of all-cause and CVD mortality.

Methods and Results
--In 1999 to 2000, glucose tolerance status was determined in 10 428 participants of the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab). After a median follow-up of 5.2 years, 298 deaths occurred (88 CVD deaths). Compared with those with normal glucose tolerance, the adjusted all-cause mortality hazard ratios (HRs) and 95% confidence intervals (CIs) for known diabetes mellitus and newly diagnosed diabetes mellitus were 2.3 (1.6 to 3.2) and 1.3 (0.9 to 2.0), respectively. The risk of death was also increased in those with impaired fasting glucose (HR 1.6, 95% CI 1.0 to 2.4) and impaired glucose tolerance (HR 1.5, 95% CI 1.1 to 2.0). Sixty-five percent of all those who died of CVD had known diabetes mellitus, newly diagnosed diabetes mellitus, impaired fasting glucose, or impaired glucose tolerance at baseline. Known diabetes mellitus (HR 2.6, 95% CI 1.4 to 4.7) and impaired fasting glucose (HR 2.5, 95% CI 1.2 to 5.1) were independent predictors for CVD mortality after adjustment for age, sex, and other traditional CVD risk factors, but impaired glucose tolerance was not (HR 1.2, 95% CI 0.7 to 2.2).

Conclusions--This study emphasizes the strong association between abnormal glucose metabolism and mortality, and it suggests that this condition contributes to a large number of CVD deaths in the general population. CVD prevention may be warranted in people with all categories of abnormal glucose metabolism.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2007, American Heart Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30020817

Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 220 times in TR Web of Science
Scopus Citation Count Cited 265 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 414 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Wed, 11 Nov 2009, 08:05:01 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.