Improved endothelial function following a 14 month resistance exercise training program in adults with type 2 diabetes

Cohen, N. D., Dunstan, D. W., Robinson, C., Vulikh, E., Zimmet, P. Z. and Shaw, J. E. 2008, Improved endothelial function following a 14 month resistance exercise training program in adults with type 2 diabetes, Diabetes research and clinical practice, vol. 79, no. 3, pp. 405-411.


Title Improved endothelial function following a 14 month resistance exercise training program in adults with type 2 diabetes
Author(s) Cohen, N. D.
Dunstan, D. W.
Robinson, C.
Vulikh, E.
Zimmet, P. Z.
Shaw, J. E.
Journal name Diabetes research and clinical practice
Volume number 79
Issue number 3
Start page 405
End page 411
Publisher Elsevier Science Publishers B.V.
Place of publication Amsterdam, Netherlands
Publication date 2008-03
ISSN 0168-8227
1872-8227
1572-1671
Keyword(s) type 2 diabetes
resistance training
endothelium
Summary Objective
We examined the effect of a 14-month progressive resistance training (PRT) program on endothelial function in both a supervised training (Center) group and non-supervised training (Home) group of patients with type 2 diabetes. We studied 28 men and women with type 2 diabetes who participated in a 14-month PRT involving an initial 2-month supervised program and a 12-month maintenance program.

Methods
Endothelial function testing was performed through laser doppler flow responses in the skin microcirculation to iontophoresis of acetylcholine (ACh) and sodium nitroprusside (NaNP) and doses of 4, 8 and 16 mC were used. Measurements of vascular response (VR), HbA1c, weight and blood pressure were performed at 0, 2 and 14 months.

Results
VR to ACh and NaNP was significantly increased at 14 months compared with baseline in both the Center and Home groups. However, no between-group differences were observed. A significant correlation was observed between HbA1c and VR to ACh at baseline and 8 weeks using 8 mC dose of ACh. There was a strong correlation between HbA1c at baseline and VR at 14 months using all three doses of ACh (4 mC:r = −0.546, p = 0.003, 8 mC:r = −0.470, p = 0.002, 16 mC:r = −0.547, p = 0.006).

Conclusions/interpretation
Endothelial function is improved following 14 months of PRT in type 2 diabetes both in a supervised and non-supervised program. Strong correlations with HbA1c including initial HbA1c levels suggest that glycemic control may be an important factor in long-term regulation of endothelial function.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2007, Elsevier Ireland Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30020824

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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