Differences in height explain gender differences in the response to the oral glucose tolerance test - the AusDiab study

Sicree, R. A., Zimmet, P. Z., Dunstan, D. W., Cameron, A. J., Welborn, T. A. and Shaw, J. E. 2008, Differences in height explain gender differences in the response to the oral glucose tolerance test - the AusDiab study, Diabetic medicine, vol. 25, no. 3, pp. 296-302.

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Title Differences in height explain gender differences in the response to the oral glucose tolerance test - the AusDiab study
Author(s) Sicree, R. A.
Zimmet, P. Z.
Dunstan, D. W.
Cameron, A. J.
Welborn, T. A.
Shaw, J. E.
Journal name Diabetic medicine
Volume number 25
Issue number 3
Start page 296
End page 302
Total pages 7
Publisher Wiley
Place of publication Chichester, England
Publication date 2008-03
ISSN 0742-3071
1464-5491
Keyword(s) epidemiology
oral glucose tolerance test
physiology
sex characteristics
Type 2 diabetes mellitus
Summary Aim To determine the extent of gender-related differences in the prevalence of glucose intolerance for the Australian population and whether body size may explain such differences.

Methods Cross-sectional data were collected from a national cohort of 11 247 Australians aged ≥ 25 years. Glucose tolerance status was assessed according to both fasting plasma glucose (FPG) and 2-h plasma glucose (2hPG) levels following a 75-g oral glucose tolerance test (OGTT). Anthropometric and glycated haemoglobin measurements were also made.

Results Undiagnosed diabetes and non-diabetic glucose abnormalities were more prevalent among men than women when based only on the FPG results (diabetes: men 2.2%, women 1.6%, P = 0.02; impaired fasting glycaemia: men 12.3%, women 6.6%, P < 0.001). In contrast 16.0% of women and 13.0% of men had a 2hPG abnormality (either diabetes or impaired glucose tolerance, P = 0.14). Women had a mean FPG 0.3 mmol/l lower than men (P < 0.001), but 2hPG 0.3 mmol/l higher (P = 0.002) and FPG-2hPG increment 0.5 mmol/l greater (P < 0.001). The gender difference in mean 2hPG and FPG-2hPG increment disappeared following adjustment for height. For both genders, those in the shortest height quartile had 2hPG levels 0.5 mmol/l higher than the tallest quartile, but height showed almost no relationship with the FPG.

Conclusions Men and women had different glycaemic profiles; women had higher mean 2hPG levels, despite lower fasting levels. It appeared that the higher 2hPG levels for women related to lesser height and may be a consequence of using a fixed glucose load in the OGTT, irrespective of body size.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2008, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30020826

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