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Central obesity as a precursor to the metabolic syndrome in the AusDiab study and Mauritius

Cameron, Adrian J., Boyko, Edward J., Sicree, Richard A., Zimmet, Paul Z., Soderberg, Stefan, Alberti, K. George M. M., Tuomilehto, Jaakko, Chitson, Pierrot and Shaw, Jonathan E. 2008, Central obesity as a precursor to the metabolic syndrome in the AusDiab study and Mauritius, Obesity, vol. 16, no. 12, pp. 2707-2716.

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Title Central obesity as a precursor to the metabolic syndrome in the AusDiab study and Mauritius
Author(s) Cameron, Adrian J.
Boyko, Edward J.
Sicree, Richard A.
Zimmet, Paul Z.
Soderberg, Stefan
Alberti, K. George M. M.
Tuomilehto, Jaakko
Chitson, Pierrot
Shaw, Jonathan E.
Journal name Obesity
Volume number 16
Issue number 12
Start page 2707
End page 2716
Total pages 10
Publisher Basingstoke, England
Place of publication Nature Publishing Group
Publication date 2008
ISSN 1930-7381
1930-739X
Summary Evidence from epidemiologic studies that central obesity precedes future metabolic change and does not occur concurrently with the appearance of the blood pressure, glucose, and lipid abnormalities that characterize the metabolic syndrome (MetS) has been lacking. Longitudinal surveys were conducted in Mauritius in 1987, 1992, and 1998, and in Australia in 2000 and 2005 (AusDiab). This analysis included men and women (aged 25 years) in three cohorts: AusDiab 2000–2005 (n = 5,039), Mauritius 1987–1992 (n = 2,849), and Mauritius 1987–1998 (n = 1,999). MetS components included waist circumference, systolic blood pressure, fasting and 2-h postload plasma glucose, high-density lipoprotein (HDL) cholesterol, triglycerides, and homeostasis model assessment of insulin sensitivity (HOMA-S) (representing insulin sensitivity). Linear regression was used to determine which baseline components predicted deterioration in other MetS components over 5 years in AusDiab and 5 and 11 years in Mauritius, adjusted for age, sex, and ethnic group. Baseline waist circumference predicted deterioration (P < 0.01) in four of the other six MetS variables tested in AusDiab, five of six in Mauritius 1987–1992, and four of six in Mauritius 1987–1998. In contrast, an increase in waist circumference between baseline and follow-up was only predicted by insulin sensitivity (HOMA-S) at baseline, and only in one of the three cohorts. These results suggest that central obesity plays a central role in the development of the MetS and appears to precede the appearance of the other MetS components.
Language eng
Field of Research 111706 Epidemiology
Socio Economic Objective 920412 Preventive Medicine
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, Nature Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30021308

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Created: Fri, 11 Dec 2009, 09:57:08 EST by Adrian Cameron

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.