The metabolic syndrome as a tool for predicting future diabetes : the AusDiab study

Cameron, A. J., Magliano, D. J., Zimmet, P. Z., Welborn, T. A., Colagiuri, S., Tonkin, A. M. and Shaw, J. E. 2008, The metabolic syndrome as a tool for predicting future diabetes : the AusDiab study, Journal of internal medicine, vol. 264, no. 2, pp. 177-186.

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Title The metabolic syndrome as a tool for predicting future diabetes : the AusDiab study
Author(s) Cameron, A. J.
Magliano, D. J.
Zimmet, P. Z.
Welborn, T. A.
Colagiuri, S.
Tonkin, A. M.
Shaw, J. E.
Journal name Journal of internal medicine
Volume number 264
Issue number 2
Start page 177
End page 186
Publisher Blackwell Scientific Publications
Place of publication Oxford, England
Publication date 2008
ISSN 0954-6820
1365-2796
Keyword(s) AusDiab
diabetes
epidemiology
longitudinal cohort
metabolic syndrome
risk prediction
Summary Objective. To compare the ability of the metabolic syndrome (MetS), a diabetes prediction model (DPM), a noninvasive risk questionnaire and individual glucose measurements to predict future diabetes.

Design. Five-year longitudinal cohort study. Tools tested included MetS definitions [World Health Organization, International Diabetes Federation, ATPIII and European Group for the study of Insulin Resistance (EGIR)], the FINnish Diabetes RIsk SCore risk questionnaire, the DPM, fasting and 2-h post load plasma glucose.

Setting. Adult Australian population.

Subjects. A total of 5842 men and women without diabetes ≥25 years. Response 58%. A total of 224 incident cases of diabetes.

Results.
In receiver operating characteristic curve analysis, the MetS was not a better predictor of incident diabetes than the DPM or measurement of glucose. The risk for diabetes among those with prediabetes but not MetS was almost triple that of those with MetS but not prediabetes (9.0% vs. 3.4%). Adjusted for component parts, the MetS was not a significant predictor of incident diabetes, except for EGIR in men [OR 2.1 (95% CI 1.2–3.7)].

Conclusions.
A single fasting glucose measurement may be more effective and efficient than published definitions of the MetS or other risk constructs in predicting incident diabetes. Diagnosis of the MetS did not confer increased risk for incident diabetes independent of its individual components, with an exception for EGIR in men. Given these results, debate surrounding the public health utility of a MetS diagnosis, at least for identification of incident diabetes, is required.
Language eng
Field of Research 111706 Epidemiology
Socio Economic Objective 920104 Diabetes
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, Blackwell Publishing Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30021310

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Created: Fri, 11 Dec 2009, 10:02:13 EST by Adrian Cameron

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