Is grand multiparity associated with an increased risk of dysglycaemia?

Simmons, D., Shaw, J. E., McKenzie, A., Eaton, S., Cameron, A.J. and Zimmet, P.Z. 2006, Is grand multiparity associated with an increased risk of dysglycaemia?, Diabetologia, vol. 49, no. 7, pp. 1522-1527.

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Title Is grand multiparity associated with an increased risk of dysglycaemia?
Author(s) Simmons, D.
Shaw, J. E.
McKenzie, A.
Eaton, S.
Cameron, A.J.
Zimmet, P.Z.
Journal name Diabetologia
Volume number 49
Issue number 7
Start page 1522
End page 1527
Publisher Springer-Verlag
Place of publication [Berlin, Germany]
Publication date 2006-07
ISSN 0012-186X
1432-0428
Keyword(s) diabetes
hysterectomy
menopause
oral contraceptive pill
parity
Summary Aims/hypothesis: We sought to determine the risk of diabetes and IGT/IFG with grand multiparity. Subjects, materials and methods: Women, aged ≥25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a household census (response 67 and 70%, respectively), subsequently attending a biomedical examination that included an oral glucose tolerance test (58% [6198] and 69% [819]). Results: After adjusting for age, obesity and socio-economic status, diabetes, but not IGT/IFG, was less common among women with a parity of 1 to 2 (odds ratio [OR]=0.64 [0.48– 0.84]) and 3 to 4 (OR=0.72 [0.53–0.96]) than in grand multiparous women. This relationship was unrelated to past hysterectomy, use of the oral contraceptive pill or menopausal status. Conclusions/interpretation: Grand multiparity is associated with an increased risk of diabetes but not of IGT/IFG.We postulate that parity accelerates transition from IGT/IFG to diabetes, more than it does transition from normal glucose tolerance to IGT/IFG.
Language eng
Field of Research 030405 Molecular Medicine
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, Springer-Verlag
Persistent URL http://hdl.handle.net/10536/DRO/DU:30021379

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