Epidemiology of metabolic syndrome

Magliano, Dianna J., Cameron, Adrian, Shaw, Jonathan E. and Zimmet, Paul Z. 2008, Epidemiology of metabolic syndrome. In Eko'e, Jean Marie, Rewers, Marian, Williams, Rhys and Zimmet, Paul (ed), The epidemiology of diabetes mellitus, Wiley-Blackwell, Chichester, England, pp.31-55.

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Title Epidemiology of metabolic syndrome
Author(s) Magliano, Dianna J.
Cameron, AdrianORCID iD for Cameron, Adrian orcid.org/0000-0002-0568-5497
Shaw, Jonathan E.
Zimmet, Paul Z.
Title of book The epidemiology of diabetes mellitus
Editor(s) Eko'e, Jean Marie
Rewers, Marian
Williams, Rhys
Zimmet, Paul
Publication date 2008
Chapter number 4
Total chapters 40
Start page 31
End page 55
Total pages 25
Publisher Wiley-Blackwell
Place of Publication Chichester, England
Summary Metabolic syndrome (MetS), also previously known by a variety of other names, including insulin resistance syndrome and the deadly quartet, is characterized by clustering of abdominal (visceral and retroperitoneal) obesity and other cardiovascular risk factors, including impaired glucose regulation, raised triglycerides, decreased high-density lipoprotein cholesterol (HDL-C), elevated blood pressure (BP).

Associated with increased risk of both type 2 diabetes and cardiovascular disease (CVD), MetS is believed to be a contributor to the modern-day epidemics of diabetes and CVD and has become a major public health challenge around the world [I]. Currently, there are five different sets of criteria which have been developed to characterize the syndrome. These definitions differ in the components included and the cut-points used for each component. The prevalence of MetS in the westernized world is significant (10-50%) and believed to be increasing over time. The pathophysiology of the syndrome is unclear, but it is thought that obesity and/or insulin resistance are key underlying components. Genetics, lifestyle and environment factors are also important causes of MetS.

This chapter provides:

• a historical overview of the evolution of MetS;
• a summary of the value of the different definitions used to characterize the syndrome;
• a summary of the underlying pathophysiology, the causes and other important risk factors of MetS;
• a summary of the evidence describing the association of MetS with CVD and diabetes;
• a summary of the prevalence of MetS using the various definitions in different countries.
ISBN 9780470017272
Edition 2nd
Language eng
Field of Research 111799 Public Health and Health Services not elsewhere classified
Socio Economic Objective 920104 Diabetes
HERDC Research category B1.1 Book chapter
ERA Research output type B Book chapter
HERDC collection year 2008
Persistent URL http://hdl.handle.net/10536/DRO/DU:30021391

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