Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet

Chen, Nora, Bezzina, Rebecca, Hinch, Edward, Lewandowski, Paul, Cameron-Smith, David, Mathai, Michael, Jois, Markandeya, Sinclair, Andrew, Begg, Denovan, Wark, John, Weisinger, Harrison and Weisinger, Richard 2009, Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet, Nutrition research, vol. 29, no. 11, pp. 784-793.

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Title Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet
Author(s) Chen, Nora
Bezzina, Rebecca
Hinch, Edward
Lewandowski, Paul
Cameron-Smith, David
Mathai, Michael
Jois, Markandeya
Sinclair, Andrew
Begg, Denovan
Wark, John
Weisinger, Harrison
Weisinger, Richard
Journal name Nutrition research
Volume number 29
Issue number 11
Start page 784
End page 793
Total pages 10
Publisher Elsevier
Place of publication New York, N.Y.
Publication date 2009-11
ISSN 0271-5317
1879-0739
Keyword(s) rat
tea
adipose tissue
gene expression
glucose tolerance test
Summary The mechanisms of how tea and epigallocatechin-3-gallate (EGCG) lower body fat are not completely understood. This study investigated long-term administration of green tea (GT), black tea (BT), or isolated EGCG (1 mg/kg per day) on body composition, glucose tolerance, and gene expression related to energy metabolism and lipid homeostasis; it was hypothesized that all treatments would improve the indicators of metabolic syndrome. Rats were fed a 15% fat diet for 6 months from 4 weeks of age and were supplied GT, BT, EGCG, or water. GT and BT reduced body fat, whereas GT and EGCG increased lean mass. At 16 weeks GT, BT, and EGCG improved glucose tolerance. In the liver, GT and BT increased the expression of genes involved in fatty acid synthesis (SREBP-1c, FAS, MCD, ACC) and oxidation (PPAR-α, CPT-1, ACO); however, EGCG had no effect. In perirenal fat, genes that mediate adipocyte differentiation were suppressed by GT (Pref-1, C/EBP-β, and PPAR-γ) and BT (C/EBP-β), while decreasing LPL, HSL, and UCP-2 expression; EGCG increased expression of UCP-2 and PPAR-γ genes. Liver triacylglycerol content was unchanged. The results suggest that GT and BT suppressed adipocyte differentiation and fatty acid uptake into adipose tissue, while increasing fat synthesis and oxidation by the liver, without inducing hepatic fat accumulation. In contrast, EGCG increased markers of thermogenesis and differentiation in adipose tissue, while having no effect on liver or muscle tissues at this dose. These results show novel and separate mechanisms by which tea and EGCG may improve glucose tolerance and support a role for these compounds in obesity prevention.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 920412 Preventive Medicine
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2009, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30021428

Document type: Journal Article
Collections: School of Medicine
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Created: Thu, 17 Dec 2009, 10:43:30 EST by Paul Lewandowski

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