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Age does not influence the bone response to treadmill exercise in female rats

Bennell, Kim L., Khan, Karim M., Warmington, Stuart, Forwood, Mark R., Coleman, Brett D., Bennett, Michael B. and Wark, John D. 2002, Age does not influence the bone response to treadmill exercise in female rats, Medicine and science in sports and exercise, vol. 34, no. 12, pp. 1958-1965.

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Title Age does not influence the bone response to treadmill exercise in female rats
Author(s) Bennell, Kim L.
Khan, Karim M.
Warmington, StuartORCID iD for Warmington, Stuart orcid.org/0000-0002-2414-7539
Forwood, Mark R.
Coleman, Brett D.
Bennett, Michael B.
Wark, John D.
Journal name Medicine and science in sports and exercise
Volume number 34
Issue number 12
Start page 1958
End page 1965
Publisher Lippincott Williams & Wilkins
Place of publication Philadelphia, Pa.
Publication date 2002-12
ISSN 0195-9131
1530-0315
Keyword(s) DXA
biomechanical testing
animal
bone
histomorphometry
Summary Purpose: Because it is believed that bone may respond to exercise differently at different ages, we compared bone responses in immature and mature rats after 12 wk of treadmill running.

Methods
: Twenty-two immature (5-wk-old) and 21 mature (17-wk-old) female Sprague Dawley rats were randomized into a running (trained, N = 10 immature, 9 mature) or a control group (controls, N = 12 immature, 12 mature) before sacrifice 12 wk later. Rats ran on a treadmill five times per week for 60-70 min at speeds up to 26 m[middle dot]min-1. Both at baseline and after intervention, we measured total body, lumbar spine, and proximal femoral bone mineral, as well as total body soft tissue composition using dual-energy x-ray absorptiometry (DXA) in vivo. After sacrificing the animals, we measured dynamic and static histomorphometry and three-point bending strength of the tibia.

Results: Running training was associated with greater differences in tibial subperiosteal area, cortical cross-sectional area, peak load, stiffness, and moment of inertia in immature and mature rats (P < 0.05). The trained rats had greater periosteal bone formation rates (P < 0.01) than controls, but there was no difference in tibial trabecular bone histomorphometry. Similar running-related gains were seen in DXA lumbar spine area (P = 0.04) and bone mineral content (BMC;P = 0.03) at both ages. For total body bone area and BMC, the immature trained group increased significantly compared with controls (P < 0.05), whereas the mature trained group gained less than did controls (P < 0.01).

Conclusion
: In this in vivo model, where a similar physical training program was performed by immature and mature female rats, we demonstrated that both age groups were sensitive to loading and that bone strength gains appeared to result more from changes in bone geometry than from improved material properties.

Language eng
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2002, American College of Sports Medicine
Persistent URL http://hdl.handle.net/10536/DRO/DU:30021862

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