HbA1c as a screening tool for detection of type 2 diabetes: A systematic review

Bennett, C.M., Gao, M. and Dharmage, S.C. 2007, HbA1c as a screening tool for detection of type 2 diabetes: A systematic review, Diabetic medicine, vol. 24, no. 4, pp. 333-343, doi: 10.1111/j.1464-5491.2007.02106.x.

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Title HbA1c as a screening tool for detection of type 2 diabetes: A systematic review
Author(s) Bennett, C.M.ORCID iD for Bennett, C.M. orcid.org/0000-0001-9581-1612
Gao, M.
Dharmage, S.C.
Journal name Diabetic medicine
Volume number 24
Issue number 4
Start page 333
End page 343
Publisher Wiley - Blackwell Publishing
Place of publication Oxford, England
Publication date 2007-04
ISSN 0742-3071
Keyword(s) diabetes
diagnosis screening
systematic review
Summary Aim: To assess the validity of glycated haemoglobin A1c (HbA1c) as a screening tool for early detection of Type 2 diabetes.

Methods: Systematic review of primary cross-sectional studies of the accuracy of HbA1c for the detection of Type 2 diabetes using the oral glucose tolerance test as the reference standard and fasting plasma glucose as a comparison.

Results: Nine studies met the inclusion criteria. At certain cut-off points, HbA1c has slightly lower sensitivity than fasting plasma glucose (FPG) in detecting diabetes, but slightly higher specificity. For HbA1c at a Diabetes Control and Complications Trial and UK Prospective Diabetes Study comparable cut-off point of ≥ 6.1%, the sensitivity ranged from 78 to 81% and specificity 79 to 84%. For FPG at a cut-off point of ≥ 6.1 mmol/l, the sensitivity ranged from 48 to 64% and specificity from 94 to 98%. Both HbA1c and FPG have low sensitivity for the detection of impaired glucose tolerance (around 50%).

Conclusions: HbA1c and FPG are equally effective screening tools for the detection of Type 2 diabetes. The HbA1c cut-off point of > 6.1% was the recommended optimum cut-off point for HbA1c in most reviewed studies; however, there is an argument for population-specific cut-off points as optimum cut-offs vary by ethnic group, age, gender and population prevalence of diabetes. Previous studies have demonstrated that HbA1c has less intra-individual variation and better predicts both micro- and macrovascular complications. Although the current cost of HbA1c is higher than FPG, the additional benefits in predicting costly preventable clinical complications may make this a cost-effective choice.
Language eng
DOI 10.1111/j.1464-5491.2007.02106.x
Field of Research 110399 Clinical Sciences not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30021869

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