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Skin prick test can identify eczematous infants at risk of asthma and allergic rhinitis Lowe, A.J., Hosking, C.S., Bennett, C.M., Carlin, J.B., Abramson, M.J., Hill, D.J. and Dharmage, S.C. 2007, Skin prick test can identify eczematous infants at risk of asthma and allergic rhinitis, Clinical and experimental allergy, vol. 37, no. 11, pp. 1624-1631. Title Skin prick test can identify eczematous infants at risk of asthma and allergic rhinitis Author(s) Lowe, A.J. Hosking, C.S. Bennett, C.M. Carlin, J.B. Abramson, M.J. Hill, D.J. Dharmage, S.C. Journal name Clinical and experimental allergy Volume number 37 Issue number 11 Start page 1624 End page 1631 Publisher Wiley-Blackwell Publishing Ltd. Place of publication Oxford, England Publication date 2007-11 ISSN 0954-7894 1365-2222 0960-2178 1472-9725 Keyword(s) allergy prevention asthma atopic disease eczema skin prick test Summary Background: Assessment of allergic sensitization is not routinely performed in infants and young children with eczema. Objective: To determine whether infants who have atopic eczema (with sensitization) are at a greater risk of developing asthma and allergic rhinitis (AR) than those with non-atopic eczema (without concurrent sensitization). Methods: The presence of eczema was prospectively documented until 2 years of age in a birth cohort of 620 infants with a family history of atopic disease. Sensitization status was determined by skin prick tests (SPTs) at 6, 12, and 24 months using six common allergens. Interviews were conducted at 6 and 7 years to determine the presence of asthma and AR. Results: Within the first 2 years of life, 28.7% of the 443 children who could be classified had atopic eczema: 20.5% had non-atopic eczema, 19.0% were asymptomatic but sensitized and 31.8% were asymptomatic and not sensitized. When compared with children with non-atopic eczema in the first 2 years of life, children with atopic eczema had a substantially greater risk of asthma [odds ratio (OR)=3.52, 95% confidence interval=1.88–6.59] and AR (OR=2.91, 1.48–5.71). The increased risk of asthma was even greater if the infant had a large SPT (OR=4.61, 2.34–9.09) indicative of food allergy. There was no strong evidence that children with non-atopic eczema had an increased risk of asthma or AR compared with asymptomatic children. Conclusion: In children with eczema within the first 2 years of life, SPT can provide valuable information on the risk of childhood asthma and AR. Language eng Field of Research 110399 Clinical Sciences not elsewhere classified HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2007, The Authors Persistent URL http://hdl.handle.net/10536/DRO/DU:30021999 Document type: Journal Article Collections: School of Health and Social Development Higher Education Research Group Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 18 Jan 2010, 11:03:03 EST Tue, 23 Feb 2010, 14:36:11 EST Tue, 23 Feb 2010, 14:37:25 EST Mon, 01 Mar 2010, 09:29:38 EST Filtered Full Citation counts:   Cited 40 times in TR Web of Science Cited 48 times in Scopus Search Google Scholar Access Statistics: 330 Abstract Views  -  Detailed Statistics Created: Mon, 18 Jan 2010, 11:03:02 EST

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