The temporal sequence of allergic sensitization and onset of infantile eczema

Lowe, A.J., Abramson, M.J., Hosking, C.S., Carlin, J.B., Bennett, C.M., Dharmage, S.C. and Hill, D.J. 2007, The temporal sequence of allergic sensitization and onset of infantile eczema, Clinical and experimental allergy, vol. 37, no. 4, pp. 536-542.


Title The temporal sequence of allergic sensitization and onset of infantile eczema
Author(s) Lowe, A.J.
Abramson, M.J.
Hosking, C.S.
Carlin, J.B.
Bennett, C.M.
Dharmage, S.C.
Hill, D.J.
Journal name Clinical and experimental allergy
Volume number 37
Issue number 4
Start page 536
End page 542
Publisher Wiley - Blackwell Publishing
Place of publication Oxford, England
Publication date 2007-04
ISSN 0954-7894
1365-2222
0960-2178
1472-9725
Keyword(s) allergy prevention
atopic disease
eczema
skin prick test
Summary Background: Eczema is commonly associated with sensitization in infants, but the causative role of sensitization in the development of eczema has been questioned.

Objective: To determine if allergic sensitization increases the risk of developing eczema, or alternatively, if eczema increases the risk of developing allergic sensitization.

Methods: We used data from the Melbourne Atopy Cohort Study, a prospective birth cohort of 552 infants with a family history of atopic disease. The main outcomes were risk of developing eczema from 6 months to 7 years of age in asymptomatic infants; and risk of developing sensitization, as measured by skin prick tests to milk, egg white, peanut, house dust mite, rye grass pollen and cat extracts, in previously unsensitized infants.

Results: Sensitization to food extracts at 6 months was associated with an increased risk of developing eczema [hazard ratio (HR) 1.63, 95% confidence interval 1.13–2.35] up to 7 years of age, after excluding infants with eczema in the first 6 months. However, eczema in the first 6 months was also associated with increased risk of new sensitization at both 1 year (HR 2.34, 1.38–3.98) and 2 years (HR 3.47, 1.65–7.32).

Conclusion: In some infants, sensitization precedes and predicts the development of eczema, while in others eczema precedes and predicts the development of sensitization. This indicates that there are multiple pathways to atopic eczema.
Language eng
Field of Research 110399 Clinical Sciences not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30022000

Document type: Journal Article
Collections: School of Health and Social Development
Higher Education Research Group
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