Do boys do the atopic march while girls dawdle?

Lowe, Adrian J., Carlin, John B., Bennett, Catherine M., Hosking, Clifford S., Abramson, Michael J., Hill, David J. and Dharmage, Shyamali C. 2008, Do boys do the atopic march while girls dawdle?, Journal of allergy and clinical immunology : official organ of American Academy of Allergy, vol. 121, no. 5, pp. 1190-1195.

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Title Do boys do the atopic march while girls dawdle?
Author(s) Lowe, Adrian J.
Carlin, John B.
Bennett, Catherine M.
Hosking, Clifford S.
Abramson, Michael J.
Hill, David J.
Dharmage, Shyamali C.
Journal name Journal of allergy and clinical immunology : official organ of American Academy of Allergy
Volume number 121
Issue number 5
Start page 1190
End page 1195
Total pages 6
Publisher Mosby
Place of publication St. Louis, Mo.
Publication date 2008-05
ISSN 0091-6749
1097-6825
Keyword(s) Atopic march
allergy prevention
eczema
asthma
Summary Background
The atopic march hypothesis suggests that infants with eczema are at increased risk of asthma. Others argue that eczema is not a risk factor for asthma unless there is also sensitization or early wheezing.
Objective
To examine the role of infantile eczema as a predictor of risk of childhood asthma, while allowing for the effects of early wheeze, sensitization, and sex, both as independent effects and possible effect modifiers.
Methods
A total of 620 infants with a family history of allergic disease was recruited. Eczema and wheeze was prospectively documented to 2 years of age. Sensitization was determined by skin prick tests at 6, 12, and 24 months to 6 common food and inhalant allergens. Interviews were conducted at 6 and 7 years to ascertain current asthma.
Results
Sufficiently complete data were available for 403 children. Eczema within the first 2 years of life was clearly associated with an increased risk of childhood asthma in boys (adjusted odds ratio, 2.45; 95% CI, 1.31-4.46) but not in girls (odds ratio, 0.88; 95% CI, 0.43-1.77; P for interaction = .031) even with adjustment for the effects of early allergic sensitization and wheeze. If these relationships are causal, an intervention to prevent eczema in boys might reduce the incidence of childhood asthma by as much as 28%.
Conclusion
Eczema in the first 2 years of life is associated with an increased risk of childhood asthma in boys, but there is no evidence of this in girls.
Language eng
Field of Research 111799 Public Health and Health Services not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, Mosby
Persistent URL http://hdl.handle.net/10536/DRO/DU:30022001

Document type: Journal Article
Collections: School of Health and Social Development
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