Associations between fatty acids in colostrum and breast milk and risk of allergic disease

Lowe, A.J., Thien, F., Stoney, R., Bennett, C.M., Hill, D., Hosking, C., Carlin, J., Abramson, M. and Dharmage, S. 2008, Associations between fatty acids in colostrum and breast milk and risk of allergic disease, Clinical and experimental allergy, vol. 38, no. 11, pp. 1745-1751, doi: 10.1111/j.1365-2222.2008.03073.x.

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Title Associations between fatty acids in colostrum and breast milk and risk of allergic disease
Author(s) Lowe, A.J.
Thien, F.
Stoney, R.
Bennett, C.M.ORCID iD for Bennett, C.M.
Hill, D.
Hosking, C.
Carlin, J.
Abramson, M.
Dharmage, S.
Journal name Clinical and experimental allergy
Volume number 38
Issue number 11
Start page 1745
End page 1751
Total pages 7
Publisher Wiley-Blackwell
Place of publication London
Publication date 2008
ISSN 0954-7894
Summary Background Exposure to n-3 polyunsaturated fatty acids (PUFA) in early life is hypothesized to offer protection against atopic disease. However, there is controversy in this area, and we have previously observed that high levels of n-3 fatty acid (FA) in colostrum are associated with increased risk of allergic sensitization.
Objective The aim of the study was to assess the relationship between FA profile in breast milk and risk of childhood atopic disease.
Methods A high-risk birth cohort was recruited, and a total of 224 mothers provided a sample of colostrum (n = 194) and/or 3-month expressed breast milk (n = 118). FA concentrations were determined by gas chromatography. Presence of eczema, asthma and rhinitis were prospectively documented up to 7 years of age.
Results High levels of n-3 22:5 FA (docosapentaenoic acid, DPA) in colostrum were associated with increased risk of infantile atopic eczema [odds ratio (OR) = 1.66 per 1 standard deviation increase, 95% confidence interval (CI) = 1.11–2.48], while total n-3 concentration in breast milk was associated with increased risk of non-atopic eczema (OR = 1.60, 95% CI = 1.03–2.50). Higher levels of total n-6 FA in colostrum were associated with increased risk of childhood rhinitis (OR = 1.59, 95% CI = 1.12–2.25). There was no evidence of associations between FA profile and risk of asthma.
Conclusion In this cohort of high-risk children, a number of modest associations were observed between FA concentrations in colostrum and breast milk and allergic disease outcomes. Further research in this area with larger sample sizes is needed.
Language eng
DOI 10.1111/j.1365-2222.2008.03073.x
Field of Research 110701 Allergy
111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, Wiley-Blackwell
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