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Measurement of lactose crystallinity using Raman spectroscopy

Murphy, Bridget M., Prescott, Stuart W. and Larson, Ian 2005, Measurement of lactose crystallinity using Raman spectroscopy, Journal of pharmaceutical and biomedical analysis, vol. 38, no. 1, pp. 186-190, doi: 10.1016/j.jpba.2004.12.013.

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Title Measurement of lactose crystallinity using Raman spectroscopy
Author(s) Murphy, Bridget M.
Prescott, Stuart W.
Larson, Ian
Journal name Journal of pharmaceutical and biomedical analysis
Volume number 38
Issue number 1
Start page 186
End page 190
Publisher Elsevier BV
Place of publication Amsterdam, Netherlands
Publication date 2005-06
ISSN 0731-7085
1873-264X
Keyword(s) raman spectroscopy
depolarisation ratio
lactose
crystallinity
anomeric form
dry powder inhalation
Summary Raman spectroscopy (RS) was used to determine the crystallinity of lactose (a commonly used carrier in dry powder inhaler (DPI) formulations). Samples of α-lactose monohydrate and amorphous lactose were prepared using ethanol precipitation and lyophilisation respectively. The anomeric forms were confirmed using DSC at a rate of 10 °C/min and heated to 250 °C. The Raman spectra of both α-lactose monohydrate and amorphous lactose were obtained. Distinguishable differences were seen between the two spectra including peak areas and intensities. Depolarisation ratios (ρ) of each form were then determined to identify the crystallinity of the lactose carrier samples. At the prominent Raman bands 865 and 1082 cm−1, significant differences in ρ values were observed for crystalline (0.80 ± 0.07, 0.89 ± 0.06 respectively) and amorphous samples (0.44 ± 0.07, 0.51 ± 0.10).
Language eng
DOI 10.1016/j.jpba.2004.12.013
Field of Research 110399 Clinical Sciences not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2004, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30022009

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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