You are not logged in.

Endurance training adaptations modulate the redox–force relationship of rat isolated slow-twitch skeletal muscles

Plant, David R., Gregorevic, Paul, Warmington, Stuart .A., Williams, David A. and Lynch, Gordon S. 2003, Endurance training adaptations modulate the redox–force relationship of rat isolated slow-twitch skeletal muscles, Clinical and experimental pharmacology and physiology, vol. 30, no. 1-2, pp. 77-81, doi: 10.1046/j.1440-1681.2002.03794x.

Attached Files
Name Description MIMEType Size Downloads

Title Endurance training adaptations modulate the redox–force relationship of rat isolated slow-twitch skeletal muscles
Author(s) Plant, David R.
Gregorevic, Paul
Warmington, Stuart .A.ORCID iD for Warmington, Stuart .A. orcid.org/0000-0002-2414-7539
Williams, David A.
Lynch, Gordon S.
Journal name Clinical and experimental pharmacology and physiology
Volume number 30
Issue number 1-2
Start page 77
End page 81
Publisher Wiley - Blackwell Publishing Asia
Place of publication Oxford, England
Publication date 2003
ISSN 0305-1870
1440-1681
Summary 1. Studies have shown that, in isolated skeletal muscles, maximum isometric force production (Po) is dependent on muscle redox state. Endurance training increases the antioxidant capacity of skeletal muscles, a factor that could impact on the force-producing capacity following exogenous exposure to an oxidant. We tested the hypothesis that 12 weeks treadmill training would increase anti-oxidant capacity in rat skeletal muscles and alter their response to exogenous oxidant exposure.

2. At the conclusion of the 12 week endurance-training programme, soleus (slow-twitch) muscles from trained rats had greater citrate synthase (CS) and catalase (CAT) activity compared with soleus muscles from untrained rats (P < 0.05).
In contrast, CAT activity of extensor digitorum longus (EDL; fast-twitch) muscles from trained rats was not different to EDL muscles of untrained rats. The CS activity was lower in EDL muscles from trained compared with untrained rats (P < 0.05).

3. Equilibration with exogenous hydrogen peroxide (H2O2, 5 mmol/L) increased the Po of soleus muscles from untrained rats for the duration of treatment (30 min), whereas the Po of EDL muscles was affected biphasically, with a small increase initially (after 5 min), followed by a more marked decrease in Po (after 30 min). The H2O2-induced increase in Po of soleus muscles from trained rats was less than that in untrained rats (P < 0.05), but no differences were observed in the Po of EDL muscles following training.

4. The results indicate that 12 weeks endurance running training conferred adaptations in soleus but not EDL muscles. These adaptations were associated with an attenuation of the oxidant-induced increase in Po of soleus muscles from trained compared with untrained rats. We conclude that endurance training-adapted soleus muscles have a slightly altered redox - force relationship.
Language eng
DOI 10.1046/j.1440-1681.2002.03794x
Field of Research 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2003, Blackwell Publishing Asia Pty Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30022037

Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in TR Web of Science
Scopus Citation Count Cited 8 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 526 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Mon, 18 Jan 2010, 11:03:37 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.