Influence of calcium ion deposition on apatite-inducing ability of porous titanium for biomedical applications

Chen, Xiao-bo, Li, Yuncang, du Plessis, Johan, Hodgson, Peter and Wen, Cui`e 2009, Influence of calcium ion deposition on apatite-inducing ability of porous titanium for biomedical applications, Acta biomaterialia, vol. 5, no. 5, pp. 1808-1820, doi: 10.1016/j.actbio.2009.01.015.

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Title Influence of calcium ion deposition on apatite-inducing ability of porous titanium for biomedical applications
Author(s) Chen, Xiao-bo
Li, Yuncang
du Plessis, Johan
Hodgson, Peter
Wen, Cui`e
Journal name Acta biomaterialia
Volume number 5
Issue number 5
Start page 1808
End page 1820
Total pages 13
Publisher Elsevier BV
Place of publication Amsterdam, Netherlands
Publication date 2009-06
ISSN 1742-7061
1878-7568
Keyword(s) porous titanium (Ti)
calcium (Ca) ion deposition
hydrothermal treatment
apatite
modified simulated body fluid (m-SBF)
Summary In the present study, the influence of calcium ion deposition on the apatite-inducing ability of porous titanium(Ti) was investigated in a modified simulated body fluid (m-SBF). Calcium hydroxide (Ca(OH)2) solutions with five degrees of saturation were used to hydrothermally deposit Ca ions on porous Ti with a porosity of 80%. Apatite-inducing ability of the Ca-ion-deposited porous Ti was evaluated by soaking them in m-SBF for up to 14 days. Scanning electron microscopy (SEM) and X-ray diffractometry (XRD) confirmed that a thin layer of calcium titanate (CaTiO3)/calcium oxide (CaO) mixture with a nanostructured porous network was produced on porous Ti substrates after hydrothermal treatment at 200 °C for 8 h. X-ray photoelectron spectroscopy results demonstrated that the content of the Ca ions deposited on Ti and the thickness of the CaTiO3/CaO layer increased with increasing saturation degree of the Ca(OH)2 solution. The thickest (over 10 nm) CaTiO3/CaO layer with the highest Ca content was achieved on the Ti treated in an oversaturated Ca(OH)2 solution (0.2 M). SEM, XRD, transmission electron microscopy and Fourier transformed infrared spectroscopy analysis indicated that the porous Ti samples deposited with the highest content of Ca ions exhibited the best apatite-inducing ability, producing a dense and complete carbonated apatite coating after a 14 day soaking in m-SBF. The present study illustrated the validity of using Ca ion deposition as a pre-treatment to endow desirable apatite-inducing ability of porous Ti for bone tissue engineering applications.
Language eng
DOI 10.1016/j.actbio.2009.01.015
Field of Research 091499 Resources Engineering and Extractive Metallurgy not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
HERDC collection year 2009
Copyright notice ©2009, Crown copyright
Persistent URL http://hdl.handle.net/10536/DRO/DU:30022579

Document type: Journal Article
Collections: Centre for Material and Fibre Innovation
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