Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more

Liongue, Clifford, Wright, Craig, Russell, Aaron P. and Ward, Alister C. 2009, Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more, International journal of biochemistry and cell biology, vol. 41, no. 12, pp. 2372-2375.

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Title Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more
Author(s) Liongue, Clifford
Wright, Craig
Russell, Aaron P.
Ward, Alister C.
Journal name International journal of biochemistry and cell biology
Volume number 41
Issue number 12
Start page 2372
End page 2375
Total pages 4
Publisher Elsevier Ltd.
Place of publication Amsterdam, The Netherlands
Publication date 2009-12
ISSN 1357-2725
1878-5875
Keyword(s) G-CSF
cytokine receptor
hematopoiesis
signaling
Summary The granulocyte colony-stimulating factor receptor (G-CSFR) plays an important role in the production, survival and activation of neutrophilic granulocytes during both normal and emergency hematopoiesis. The G-CSFR also participates in the development of other myeloid lineages, the mobilization of hematopoietic stem cells and myeloid cell migration. This has lead to several important clinical applications for its ligand, G-CSF. More recently, additional important roles for G-CSFR have emerged outside the hematopoietic system, such as in the protection and repair of a diverse range of tissues, including muscle, liver and neural tissue, providing further scope for developing G-CSF as a therapeutic agent. The G-CSFR has also been implicated in the etiology of disease, with mutations/variants of G-CSFR implicated in neutropenia, myelodysplasia and leukemia. Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.
Language eng
Field of Research 110707 Innate Immunity
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2009, Elsevier Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30022875

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