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Aptasensors design considerations

Lim, Y. C., Kouzani, A. Z. and Duan, W. 2009, Aptasensors design considerations, in Computational intelligence and intelligent systems, Springer, Berlin, Germany, pp.118-127.

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Title Aptasensors design considerations
Author(s) Lim, Y. C.
Kouzani, A. Z.
Duan, W.
Title of book Computational intelligence and intelligent systems
Editor(s) Cai, Zhihua
Li, Zhenhua
Kang, Zhuo
Liu, Yong
Publication date 2009
Series Communications in computer and information science ; volume 51
Chapter number 14
Total chapters 54
Start page 118
End page 127
Total pages 10
Publisher Springer
Place of Publication Berlin, Germany
Keyword(s) aptamer
immobilization
aptasensor
Summary With the advancement of biotechnology, aptamer-based sensors have received intense attention in both research and commercial worlds. This is driven by the advantages of small molecule size, chemical stability, and cost effectiveness of aptamers over the conventional analyte detection using antibodies. This paper explores the aptasensors from a designer perspective and discusses the aptasensor design considerations by giving an overview of surface functionalization techniques and the existing mechanisms used to detect biomolecular interactions. It also expounds the factors that influence the accuracy and sensitivity of aptasensors.
ISBN 9783642049613
9783642049620
ISSN 1865-0929
1865-0937
Language eng
Field of Research 091306 Microelectromechanical Systems (MEMS)
100402 Medical Biotechnology Diagnostics (incl Biosensors)
Socio Economic Objective 920203 Diagnostic Methods
HERDC Research category B1 Book chapter
HERDC collection year 2009
Copyright notice ©2009, Springer-Verlag
Persistent URL http://hdl.handle.net/10536/DRO/DU:30022918

Document type: Book Chapter
Collections: School of Medicine
School of Engineering
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Created: Fri, 05 Feb 2010, 10:22:38 EST by Abbas Kouzani