Dietary protein level interacts with ω-3 polyunsaturated fatty acid deficiency to induce hypertension

Dietary protein level interacts with ω-3 polyunsaturated fatty acid deficiency to induce hypertension

Begg, Denovan P., Sinclair, Andrew J., Stahl, Lauren A., Garg, Manohar L., Jois, Mark and Weisinger, Richard S. 2010, Dietary protein level interacts with ω-3 polyunsaturated fatty acid deficiency to induce hypertension, American journal of hypertension, vol. 23, no. 2, pp. 125-128.

Attached Files (Some files may be inaccessible until you login with your Deakin Research Online credentials)
Name			Description	MIMEType		Size	Downloads

Title	Dietary protein level interacts with ω-3 polyunsaturated fatty acid deficiency to induce hypertension
Author(s)	Begg, Denovan P. Sinclair, Andrew J. Stahl, Lauren A. Garg, Manohar L. Jois, Mark Weisinger, Richard S.
Journal name	American journal of hypertension
Volume number	23
Issue number	2
Start page	125
End page	128
Publisher	Nature Publishing Group
Place of publication	London, England
Publication date	2010
ISSN	0895-7061 1941-7225 1139-5990
Keyword(s)	ω-3 blood pressure dietary protein hypertension
Summary	Background : Dietary ω-3 fatty acid deficiency can lead to hypertension in later life; however, hypertension is affected by numerous other dietary factors. We examined the effect of altering the dietary protein level on blood pressure in animals deficient or sufficient in ω-3 fatty acids. Methods : Female rats were placed on one of four experimental diets 1 week prior to mating. Diets were either deficient (10% safflower oil; DEF) or sufficient (7% safflower oil, 3% flaxseed oil; SUF) in ω-3 fatty acids and contained 20 or 30% casein (DEF20, SUF20, DEF30, SUF30). Offspring were maintained on the maternal diet for the duration of the experiment. At 12, 18, 24, and 30 weeks, blood pressure was assessed by tail cuff plethysmography. Results : At both 12 and 18 weeks of age, no differences in blood pressure were observed based on diet, however, by 24 weeks hypertension was evident in DEF30 animals; there were no blood pressure differences between the other groups. This hypertension in DEF30 group was increased at 30 weeks, with systolic, diastolic, and mean arterial pressure all elevated. Conclusions : These results indicate that the hypertension previously attributed to ω-3 fatty acid deficiency is dependent on additional dietary factors, including protein content. Furthermore, this study is the first to plot the establishment of ω-3 fatty acid deficiency hypertension over time.
Language	eng
Field of Research	111103 Nutritional Physiology
Socio Economic Objective	970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category	C1 Refereed article in a scholarly journal
Copyright notice	©2010, American Journal of Hypertension, Ltd.
Persistent URL	http://hdl.handle.net/10536/DRO/DU:30023002

Document type:	Journal Article
Collections:	School of Exercise and Nutrition Sciences School of Medicine

Citation counts:	Cited 9 times in TR Web of Science Cited 12 times in Scopus
Access Statistics:	344 Abstract Views, 3 File Downloads - Detailed Statistics
Created:	Wed, 10 Feb 2010, 11:53:16 EST by Sally Morrigan

Deakin Research Online

Dietary protein level interacts with ω-3 polyunsaturated fatty acid deficiency to induce hypertension

Study

Research

Access Deakin

On campus

Connect