Dietary protein level interacts with ω-3 polyunsaturated fatty acid deficiency to induce hypertension

Begg, Denovan P., Sinclair, Andrew J., Stahl, Lauren A., Garg, Manohar L., Jois, Mark and Weisinger, Richard S. 2010, Dietary protein level interacts with ω-3 polyunsaturated fatty acid deficiency to induce hypertension, American journal of hypertension, vol. 23, no. 2, pp. 125-128, doi: 10.1038/ajh.2009.198.

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Title Dietary protein level interacts with ω-3 polyunsaturated fatty acid deficiency to induce hypertension
Author(s) Begg, Denovan P.
Sinclair, Andrew J.
Stahl, Lauren A.
Garg, Manohar L.
Jois, Mark
Weisinger, Richard S.
Journal name American journal of hypertension
Volume number 23
Issue number 2
Start page 125
End page 128
Total pages 4
Publisher Nature Publishing Group
Place of publication London, England
Publication date 2010
ISSN 0895-7061
Keyword(s) ω-3
blood pressure
dietary protein
Summary Background : Dietary ω-3 fatty acid deficiency can lead to hypertension in later life; however, hypertension is affected by numerous other dietary factors. We examined the effect of altering the dietary protein level on blood pressure in animals deficient or sufficient in ω-3 fatty acids.

Methods : Female rats were placed on one of four experimental diets 1 week prior to mating. Diets were either deficient (10% safflower oil; DEF) or sufficient (7% safflower oil, 3% flaxseed oil; SUF) in ω-3 fatty acids and contained 20 or 30% casein (DEF20, SUF20, DEF30, SUF30). Offspring were maintained on the maternal diet for the duration of the experiment. At 12, 18, 24, and 30 weeks, blood pressure was assessed by tail cuff plethysmography.

Results : At both 12 and 18 weeks of age, no differences in blood pressure were observed based on diet, however, by 24 weeks hypertension was evident in DEF30 animals; there were no blood pressure differences between the other groups. This hypertension in DEF30 group was increased at 30 weeks, with systolic, diastolic, and mean arterial pressure all elevated.

Conclusions : These results indicate that the hypertension previously attributed to ω-3 fatty acid deficiency is dependent on additional dietary factors, including protein content. Furthermore, this study is the first to plot the establishment of ω-3 fatty acid deficiency hypertension over time.
Language eng
DOI 10.1038/ajh.2009.198
Field of Research 111103 Nutritional Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, American Journal of Hypertension, Ltd.
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Collections: School of Exercise and Nutrition Sciences
School of Medicine
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