Effect of low and high glycaemic index diets on developing the risk of metabolic syndrome in rats

Chandrasekara, A., Denyer, G. and Caterson, I. 2005, Effect of low and high glycaemic index diets on developing the risk of metabolic syndrome in rats, Tropical agricultural research, vol. 17, pp. 1-8.

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Title Effect of low and high glycaemic index diets on developing the risk of metabolic syndrome in rats
Author(s) Chandrasekara, A.
Denyer, G.
Caterson, I.
Journal name Tropical agricultural research
Volume number 17
Start page 1
End page 8
Publisher University of Peradeniya
Place of publication Peradeniya, Sri Lanka
Publication date 2005
ISSN 1016-1422
Summary Several observational studies have shown that the chronic consumption of high glycaemic index diet is associated with an increased risk of developing metabolic syndrome.  This study was performed to identify the direct influences on the lipid profile and the adipose tissue deposition and the subsequent development of the risk of metabolic syndrome in rats by feeding diets of low glycaemic index (LGI) and high glycaemic index (HGI). Fifty rat weanlings (three weeks old) were equally divided into two groups and fed on either low glycaemic index diet based on high amylose, or isocaloric high glycacmic index diet for 12 weeks. Postprandial blood and tissue samples were collected at the end of the 12 weeks of feeding. The total white adipose tissue weights of the HGl fed rats (24.74 ± 0.53 glrat) were significantly higher than the LGl fed rats (15.37 ± 0.36 gh·at). The HO! led rats had higher postprandial leptin concentrations (1.86 ± 0.17 ng/ml) than LGI fed rats (1.34 ± 0.12 ng/ml). The postprandial insulin, and postprandial insulin glucose ratio were higher in the HGI fed rats (7.06 ± 0.90 ng/ml and 0.67 ± 0.01 ng/mlxmM) compared to the LGl fed rats (3.91 ± 0.4 ng/ml and 0.44 ± 0.01 ng/mlxmM). Triglycerides of the l-IGI fed rats showed higher values (I .56 ± 0.10 mM) than the LO! fed rats (l.07 ± 0.08 mM). The results indicated that LGI feeding was beneficial in preventing the conditions enhancing the cardio vascular disease whereas long-term feeding of HGI diet may increase the risk of developing metabolic syndrome in rats.
Language eng
Field of Research 111102 Dietetics and Nutrigenomics
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30023040

Document type: Journal Article
Collection: School of Medicine
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