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Studies of the human lymphocyte P2Z receptor and its activation of phospholipase D

Gargett, Caroline Eve. 1997, Studies of the human lymphocyte P2Z receptor and its activation of phospholipase D, Ph.D. thesis, Deakin University.

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Title Studies of the human lymphocyte P2Z receptor and its activation of phospholipase D
Author Gargett, Caroline Eve.
Institution Deakin University
Faculty Faculty of Science and Technology
Degree name Ph.D.
Date submitted 1997
Keyword(s) Adenosine triphosphate - Receptors
Lymphocytes - Receptors
Lymphocytes - Research
Summary Adenosine triphosphate (ATP) is an important energy storage chemical inside all cells. Human lymphocytes have P2Z receptors. This study showed that when ATP was added added to the outside of lymphocytes it attached to the P2Z receptor opening a channel through which tiny amounts of calcium entered the cell switching on the enzyme phospholipase D. Two new and potent inhibitors for the P2Z receptor, KN-62 and KN-04, which have no effect on the other two types of ATP receptor were discovered. They are several hundred times more potent than currently available inhibitors.
Language eng
Description of original xx, 194 leaves : ill. ; 30 cm.
Dewey Decimal Classification 572.475
Persistent URL http://hdl.handle.net/10536/DRO/DU:30023407

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.