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Liver fat metabolism, obesity and diabetes in Psammomys obesis

Lewandowski, Paul. 1999, Liver fat metabolism, obesity and diabetes in Psammomys obesis, Ph.D. thesis, School of Health Sciences, Deakin University.

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Title Liver fat metabolism, obesity and diabetes in Psammomys obesis
Author Lewandowski, Paul.
Institution Deakin University
School School of Health Sciences
Faculty Faculty of Health and Behavioural Sciences
Degree name Ph.D.
Date submitted 1999
Keyword(s) Obesity - Etiology
Diabetes - Etiology
Liver - Metabolism
Summary Results demonstrated that fat accumulation within the liver was not a primary defect in the aetiology and pathogenesis of obesity and typeII diabetes. Fat accumulating in the liver was not the result of changes in the gene expression of key enzymes and proteins involved in hepatic fat metabolism. Howeverchanges in the mRNA level of transcription factors PPAR[alpha] and SREBP-1C was associated with the development of diabetes and the gene expression of these two transcription factors was associated with changes in diabetic status.
Language eng
Description of original xvi, 270 leaves ; 30 cm.
Dewey Decimal Classification 573.384
Persistent URL http://hdl.handle.net/10536/DRO/DU:30023469

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.