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The omega-3 fatty acid, DHA, decreases neuronal cell death in association with altered zinc transport

Suphioglu, Cenk, De Mel, Damitha, Kumar, Loveleen, Sadli, Nadia, Freestone, David, Michalczyk, Agnes, Sinclair, Andrew and Ackland, M. Leigh 2010, The omega-3 fatty acid, DHA, decreases neuronal cell death in association with altered zinc transport, FEBS letters, vol. 584, no. 3, pp. 612-618.

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Title The omega-3 fatty acid, DHA, decreases neuronal cell death in association with altered zinc transport
Author(s) Suphioglu, Cenk
De Mel, Damitha
Kumar, Loveleen
Sadli, Nadia
Freestone, David
Michalczyk, Agnes
Sinclair, Andrew
Ackland, M. Leigh
Journal name FEBS letters
Volume number 584
Issue number 3
Start page 612
End page 618
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2010-02
ISSN 0014-5793
1873-3468
Keyword(s) DHA
omega-3 fatty acid
zinc
ZnT3
M17 human neuronal cell
apoptosis
Summary Docosahexaenoic acid (DHA) is the major polyunsaturated fatty acid in neuronal cell membranes. We hypothesize that DHA induces a decrease in neuronal cell death through reduced ZnT3 expression and zinc uptake. Exposure of M17 cells to DHA-deficient medium increased the levels of active caspase-3, relative to levels in DHA-replete cells, confirming the adverse effects of DHA deficiency in promoting neuronal cell death. In DHA-treated M17 cells, zinc uptake was 65% less and ZnT3 mRNA and protein levels were reduced in comparison with DHA-depleted cells. We propose that the neuroprotective function of DHA is exerted through a reduction in cellular zinc levels that in turn inhibits apoptosis.
Language eng
Field of Research 111103 Nutritional Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
HERDC collection year 2010
Copyright notice ©2009, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30023634

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