Should capillary blood glucose measurements be used in population surveys?

Tirimacco, R., Tideman, P. A., Dunbar, J., Simpson, P. A., Philpot, B., Laatikainen, T. and Janus, E. 2010, Should capillary blood glucose measurements be used in population surveys?, International journal of diabetes mellitus, vol. 2, no. 1, pp. 24-27.

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Title Should capillary blood glucose measurements be used in population surveys?
Author(s) Tirimacco, R.
Tideman, P. A.
Dunbar, J.
Simpson, P. A.
Philpot, B.
Laatikainen, T.
Janus, E.
Journal name International journal of diabetes mellitus
Volume number 2
Issue number 1
Start page 24
End page 27
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2010-04
ISSN 1877-5934
Keyword(s) capillary blood glucose
type 2 diabetes
population health
risk factor surveys
point-of-care testing
Summary Objective
To determine the accuracy and appropriateness of capillary blood glucose testing in population surveys.
Materials and methods

Capillary blood glucose using the Rochec ACCU-CHEK instrument and Advantage 11 Test Strips was compared to a laboratory instrument. Three independent cross-sectional risk factor surveys (n=1432) and baseline individuals from the Greater Green Triangle Diabetes Prevention Project (n=341) provided both fasting plasma and capillary blood glucose measurements. Accuracy of capillary glucoses was assessed using the ISO 15197 standard. The median age of the participants was 71years, ranging from 25 to 84years. There were 799 males and 974 females.
Results
Capillary glucose method had poorer precision at lower concentrations (CV: 9.50%, mean=3.09mmol/L, CV: 4.90%, mean=16.78mmol/L, n=233 replicates). Individual discrepancies were seen across the measuring range (2.8–19.9mmol/L, n=1773). In total, 94.5% of results fell within the minimum acceptable accuracy standards. This was slightly short of the 95% of results required to meet the ISO 15197 standard. The prevalence of diabetes in the study population using glucose 7.0mmol/L was 2.4% (95%CI 1.8–3.3%) according to fasting plasma glucose and 2.8% (2.1–3.8%) according to fasting capillary glucose. The lower WHO-defined cut-off of 6.1mmol/L for capillary blood glucose testing gave a prevalence of 10.7% (9.0–12.5%).
Conclusions
This study of matched capillary and plasma glucose results concludes that while it is appropriate to use fasting capillary glucose levels to determine the prevalence of diabetes in populations, it should not be used to reliably diagnose diabetes in individuals.
Notes Published online : 07 January 2010.
Language eng
Field of Research 111799 Public Health and Health Services not elsewhere classified
Socio Economic Objective 920208 Health Policy Evaluation
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2009, International Journal of Diabetes Mellitus
Persistent URL http://hdl.handle.net/10536/DRO/DU:30023648

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Created: Thu, 11 Feb 2010, 10:28:53 EST by Liz Jackway

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