An aqueous Chlorella extract inhibits IL-5 production by mast cells in vitro and reduces ovalbumin-induced eosinophil infiltration in the airway in mice in vivo

Kralovec, J. A., Power, M. R., Liu, F., Maydanski, E., Ewart, H. S., Watson, L. V., Barrow, C. J. and Lin, T. J. 2005, An aqueous Chlorella extract inhibits IL-5 production by mast cells in vitro and reduces ovalbumin-induced eosinophil infiltration in the airway in mice in vivo, International immunopharmacology, vol. 5, no. 4, pp. 689-698.

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Title An aqueous Chlorella extract inhibits IL-5 production by mast cells in vitro and reduces ovalbumin-induced eosinophil infiltration in the airway in mice in vivo
Formatted title An aqueous Chlorella extract inhibits IL-5 production by mast cells in vitro and reduces ovalbumin-induced eosinophil infiltration in the airway in mice in vivo
Author(s) Kralovec, J. A.
Power, M. R.
Liu, F.
Maydanski, E.
Ewart, H. S.
Watson, L. V.
Barrow, C. J.
Lin, T. J.
Journal name International immunopharmacology
Volume number 5
Issue number 4
Start page 689
End page 698
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2005-04
ISSN 1567-5769
Summary An aqueous extract of the edible microalga, Chlorella pyrenoidosa (CP) (1), has recently been tested for its immunomodulatory effects in a human clinical trial. Here, the CP extract was dialyzed and fractionated using Sephadex G 100 chromatography. The effects of a dialyzed aqueous CP extract, fraction 2, on mast cell mediator release in vitro and ovalbumin-induced allergic airway inflammation in vivo were examined. In vitro, treatment of mouse bone marrow-derived mast cells with 2 for 18 h significantly inhibited antigen (trinitrophenyl-BSA)-induced IL-5 production. In vivo, treatment of mice with 2 during ovalbumin sensitization and stimulation process significantly reduced eosinophil and neutrophil infiltration in the airways. Moreover, fractions obtained by size exclusion chromatography of 2 inhibited IgE-dependent cytokine GM-CSF production from human cord blood-derived mast cells. Taken together, these results suggest that 2 is composed of biopolymers with anti-allergic potential.
Language eng
Field of Research 110705 Humoural Immunology and Immunochemistry
110701 Allergy
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2005, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30023808

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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