Higher leptin levels in Asian Indians than Creoles and Europids : a potential explanation for increased metabolic risk

Lilja, M., Rolandsson, O., Shaw, J. E., Pauvaday, V., Cameron, A. J., Tuomilehto, J., Alberti, K. G. M. M., Zimmet, P. Z. and Soderberg, S. 2010, Higher leptin levels in Asian Indians than Creoles and Europids : a potential explanation for increased metabolic risk, International journal of obesity, vol. 34, no. 5, pp. 878-885.

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Title Higher leptin levels in Asian Indians than Creoles and Europids : a potential explanation for increased metabolic risk
Author(s) Lilja, M.
Rolandsson, O.
Shaw, J. E.
Pauvaday, V.
Cameron, A. J.
Tuomilehto, J.
Alberti, K. G. M. M.
Zimmet, P. Z.
Soderberg, S.
Journal name International journal of obesity
Volume number 34
Issue number 5
Start page 878
End page 885
Total pages 8
Publisher Nature Publishing Group
Place of publication London, England
Publication date 2010-05
ISSN 0307-0565
1476-5497
Keyword(s) leptin
intra-individual stability
season
ethnicity
Summary Background and purpose: Leptin predicts cardiovascular diseases and type 2 diabetes, diseases to which Asian Indians are highly susceptible. As a risk marker, leptin’s intra-individual and seasonal stability is unstudied and only small studies have compared leptin levels in Asian Indians with other populations. The aim of this study was to explore ethnicity related differences in leptin levels and its intra-individual and seasonal stability.

Methods: Leptin and anthropometric data from the northern Sweden MONICA (3513 Europids) and the Mauritius Non-communicable Disease (2480 Asian Indians and Creoles) studies were used. In both studies men and women, 25- to 74-year old, participated in both an initial population survey and a follow-up after 5–13 years. For the analysis of seasonal leptin variation, a subset of 1780 participants, 30- to 60-year old, in the Vasterbotten Intervention Project was used.

Results: Asian Indian men and women had higher levels of leptin, leptin per body mass index (BMI) unit (leptin/BMI) or per cm in waist circumference (WC; leptin/waist) than Creoles and Europids when adjusted for BMI (all P<0.0005) or WC (all P<0.005). In men, Creoles had higher leptin, leptin/BMI and leptin/waist than Europids when adjusted for BMI or WC (all P<0.0005). In women, Creoles had higher leptin/BMI and leptin/waist than Europids only when adjusted for WC (P<0.0005). Asian Indian ethnicity in both sexes, and Creole ethnicity in men, was independently associated with high leptin levels. The intra-class correlation for leptin was similar (0.6–0.7), independently of sex, ethnicity or follow-up time. No seasonal variation in leptin levels was seen.

Conclusion: Asian Indians have higher levels of leptin, leptin/BMI and leptin/waist than Creoles and Europids. Leptin has a high intra-individual stability and seasonal leptin variation does not appear to explain the ethnic differences observed here.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, Macmillan Publishers Limited
Persistent URL http://hdl.handle.net/10536/DRO/DU:30024066

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