Incorporation and metabolism of punicic acid in healthy young humans

Yuan, Gaofeng, Sinclair, Andrew J., Xu, Chaojiong and Li, Duo 2009, Incorporation and metabolism of punicic acid in healthy young humans, Molecular nutrition and food research, vol. 53, no. 10, pp. 1336-1342, doi: 10.1002/mnfr.200800520.

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Title Incorporation and metabolism of punicic acid in healthy young humans
Author(s) Yuan, Gaofeng
Sinclair, Andrew J.
Xu, Chaojiong
Li, Duo
Journal name Molecular nutrition and food research
Volume number 53
Issue number 10
Start page 1336
End page 1342
Total pages 7
Publisher Wiley
Place of publication Weinheim, Germany
Publication date 2009-10
ISSN 1613-4125
Summary The objective of this study was to investigate the incorporation and metabolism of punicic acid (PA, cis9,trans11,cis13-18:3) in healthy young humans. The study was a randomized controlled trial. After 7 days adaptation with sunflower seed kernels supplementation, 30 subjects were then divided into the control and test group (n = 15). The test group was supplemented with Trichosanthes kirilowii (TK) seed kernels containing 3 g of PA per day in the form of triacylglycerols for 28 days. The control group was provided with sunflower seed kernels. After consumption of TK seeds containing 3 g PA per day for 28 days, the proportion of PA was increased from 0.00 to 0.47% in plasma and 0.00 to 0.37% in red blood cell membranes (RBCM), respectively. The proportion of cis9,trans11-18:2 was increased from 0.05 to 0.23% in plasma and 0.03 to 0.17% in RBCM after 28 days of intervention, respectively. Our results suggest that PA can be effectively incorporated into human plasma and RBCM, and is also associated with the increasing proportion of cis9,trans11-18:2 in humans, presumably as a result of metabolism by a saturation reaction. Edible TK seeds could be a potential dietary source of conjugated linoleic acids.
Language eng
DOI 10.1002/mnfr.200800520
Field of Research 111103 Nutritional Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2009, Wiley
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Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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