Comparative effects of tuna oil and salmon oil on liver lipid metabolism and fatty acid concentrations in rats

Huang, Tao, Sinclair, Andrew J., Shen, Lirong, Yang, Bin and Li, Duo 2009, Comparative effects of tuna oil and salmon oil on liver lipid metabolism and fatty acid concentrations in rats, Journal of food lipids, vol. 16, no. 4, pp. 436-451.

Attached Files
Name Description MIMEType Size Downloads

Title Comparative effects of tuna oil and salmon oil on liver lipid metabolism and fatty acid concentrations in rats
Author(s) Huang, Tao
Sinclair, Andrew J.
Shen, Lirong
Yang, Bin
Li, Duo
Journal name Journal of food lipids
Volume number 16
Issue number 4
Start page 436
End page 451
Total pages 16
Publisher Wiley - Blackwell Publishing
Place of publication Malden, Mass.
Publication date 2009-11-26
ISSN 1065-7258
1745-4522
Summary The comparative effect of tuna oil (TO) and salmon oil (SO) on the plasma and liver lipid and fatty acid compositions in Sprague Dawley rats was investigated. The total triacylglycerol (TG) and total cholesterol (TC) concentrations in liver was significantly decreased in the TO group; TG level in liver was also significantly decreased in the SO group. The mRNA expression of HMG-CoA reductase in liver was significantly down-regulated in the TO and SO groups relative to the control group. The plasma TG and TC were decreased in TO, but not in SO; plasma low-density lipoprotein and very low-density lipoprotein levels in TO and SO were decreased compared with the control group. The total n-3 polyunsaturated fatty acid (PUFA) in plasma and liver phospholipids was significantly elevated in the TO and SO. Docosahexaenoic acid (22:6n-3) and eicosapentaenoic acid (20:5n-3) in tissues were significantly increased in the TO and SO, respectively. In this study, TO had a more beneficial effect on liver TC and plasma TG, TC, high-density lipoprotein in rats than SO. The likely mechanism for lowering liver and plasma cholesterol by n-3 PUFA is to suppress the mRNA expression of gene encoding HMG-CoA reductase responsible for cholesterol biosynthesis.

PRACTICAL APPLICATIONS

The beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) from fish and fish oil on human health is derived from their role in modulating membrane lipid composition and affecting metabolic and signal-transduction pathways. In the present study, we demonstrated that n-3 PUFA, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) from tuna and salmon oils can be effectively incorporated into tissue membranes. Tuna oil rich in DHA has more beneficial effect on liver total cholesterol (TC) and plasma triglyceride, TC and HDL in rats than salmon oil, which is rich in EPA. The present data could provide information for the potential application of fish oils as components of functional food, and selected for fortification with different fish oils.
Language eng
Field of Research 111103 Nutritional Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2009, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30024886

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in TR Web of Science
Scopus Citation Count Cited 4 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 507 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Fri, 05 Mar 2010, 08:13:26 EST by Sally Morrigan

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.