Ankylosing spondylitis patients commencing biologic therapy have high baseline levels of comorbidity : a report from the Australian Rheumatology Association Database

Oldroyd, John, Schachna, Lionel, Buchbinder, Rachelle, Staples, Margaret P., Murphy, Bridie, Bond, Molly, Briggs, Andrew, Lassere, Marissa and March, Lyn 2009, Ankylosing spondylitis patients commencing biologic therapy have high baseline levels of comorbidity : a report from the Australian Rheumatology Association Database, International journal of rheumatology, vol. 2009, pp. 1-10.

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Title Ankylosing spondylitis patients commencing biologic therapy have high baseline levels of comorbidity : a report from the Australian Rheumatology Association Database
Author(s) Oldroyd, John
Schachna, Lionel
Buchbinder, Rachelle
Staples, Margaret P.
Murphy, Bridie
Bond, Molly
Briggs, Andrew
Lassere, Marissa
March, Lyn
Journal name International journal of rheumatology
Volume number 2009
Start page 1
End page 10
Publisher Hindawi Publishing Corp.
Place of publication New York, N.Y.
Publication date 2009
ISSN 1687-9260
1687-9279
Summary Aims: To compare the baseline characteristics of a population-based cohort of patients with ankylosing spondylitis (AS) commencing biological therapy to the reported characteristics of bDMARD randomised controlled trials (RCTs) participants.
Methods: Descriptive analysis of AS participants in the Australian Rheumatology Association Database (ARAD) who were commencing bDMARD therapy.
Results: Up to December 2008, 389 patients with AS were enrolled in ARAD. 354 (91.0%) had taken bDMARDs at some time, and 198 (55.9%) completed their entry questionnaire prior to or within 6 months of commencing bDMARDs. 131 (66.1%) had at least one comorbid condition, and 24 (6.8%) had a previous malignancy (15 nonmelanoma skin, 4 melanoma, 2 prostate, 1 breast, cervix, and bowel). Compared with RCT participants, ARAD participants were older, had longer disease duration and higher baseline disease activity.
Conclusions: AS patients commencing bDMARDs in routine care are significantly different to RCT participants and have significant baseline comorbidities.
Language eng
Field of Research 110322 Rheumatology and Arthritis
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2009, John Oldroyd et al.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30024913

Document type: Journal Article
Collection: Public Health Research, Evaluation, and Policy Cluster
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