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Exercise and MEF2–HDAC interactions.

McGee, Sean L. 2007, Exercise and MEF2–HDAC interactions., Applied physiology, nutrition and metabolism, vol. 32, no. 5, pp. 852-856.

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Title Exercise and MEF2–HDAC interactions.
Author(s) McGee, Sean L.
Journal name Applied physiology, nutrition and metabolism
Volume number 32
Issue number 5
Start page 852
End page 856
Publisher N R C Research Press
Place of publication Ottawa, Ontario
Publication date 2007-10
ISSN 1715-5312
1715-5320
Summary Exercise increases the metabolic capacity of skeletal muscle, which improves whole-body energy homeostasis and contributes to the positive health benefits of exercise. This is, in part, mediated by increases in the expression of a number of metabolic enzymes, regulated largely at the level of transcription. At a molecular level, many of these genes are regulated by the class II histone deacetylase (HDAC) family of transcriptional repressors, in particular HDAC5, through their interaction with myocyte enhancer factor 2 transcription factors. HDAC5 kinases, including 5′-AMP-activated protein kinase and protein kinase D, appear to regulate skeletal muscle metabolic gene transcription by inactivating HDAC5 and inducing HDAC5 nuclear export. These mechanisms appear to participate in exercise-induced gene expression and could be important for skeletal muscle adaptations to exercise.
Language eng
Field of Research 060114 Systems Biology
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, NRC Canada
Persistent URL http://hdl.handle.net/10536/DRO/DU:30025017

Document type: Journal Article
Collections: School of Medicine
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Created: Fri, 12 Mar 2010, 10:50:14 EST by Sean McGee