AMPK and transcriptional regulation

McGee, Sean L. and Hargreaves, Mark 2008, AMPK and transcriptional regulation, Frontiers in bioscience, vol. 13, pp. 3022-3033.

Title	AMPK and transcriptional regulation
Author(s)	McGee, Sean L. Hargreaves, Mark
Journal name	Frontiers in bioscience
Volume number	13
Start page	3022
End page	3033
Publisher	Frontiers in bioscience
Place of publication	Albertson, NY
Publication date	2008
ISSN	1093-9946 1094-3935 1093-4715 1945-0494 1945-0516
Summary	The AMP-activated protein kinase (AMPK) is an energy sensing enzyme that once activated, promotes energy production and limits energy utilisation to ensure cellular survival. In addition to targeting numerous metabolic enzymes for this purpose, it is becoming apparent that AMPK can also regulate a number of transcriptional processes. These processes ensure cell survival through the inhibition of cell cycle and growth mechanisms, and also prepare the cell for future perturbations in energy balance by increasing the capacity of the cell to produce ATP. While these adaptations might be inextricably linked through regulation of the proliferation-differentiation process, recent studies have identified a number of transcriptional regulators as AMPK substrates that give insights into the regulation of transcription by AMPK in a number of metabolically active tissues.
Language	eng
Field of Research	060114 Systems Biology
Socio Economic Objective	970106 Expanding Knowledge in the Biological Sciences
HERDC Research category	C1.1 Refereed article in a scholarly journal
Persistent URL	http://hdl.handle.net/10536/DRO/DU:30025020

Document type:	Journal Article
Collection:	School of Medicine

Citation counts:	Cited 54 times in TR Web of Science Cited 53 times in Scopus
Access Statistics:	371 Abstract Views - Detailed Statistics
Created:	Fri, 12 Mar 2010, 11:02:16 EST by Sean McGee

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