AMPK and transcriptional regulation

McGee, Sean L. and Hargreaves, Mark 2008, AMPK and transcriptional regulation, Frontiers in bioscience, vol. 13, pp. 3022-3033.


Title AMPK and transcriptional regulation
Author(s) McGee, Sean L.
Hargreaves, Mark
Journal name Frontiers in bioscience
Volume number 13
Start page 3022
End page 3033
Publisher Frontiers in bioscience
Place of publication Albertson, NY
Publication date 2008
ISSN 1093-9946
1094-3935
1093-4715
1945-0494
1945-0516
Summary The AMP-activated protein kinase (AMPK) is an energy sensing enzyme that once activated, promotes energy production and limits energy utilisation to ensure cellular survival. In addition to targeting numerous metabolic enzymes for this purpose, it is becoming apparent that AMPK can also regulate a number of transcriptional processes. These processes ensure cell survival through the inhibition of cell cycle and growth mechanisms, and also prepare the cell for future perturbations in energy balance by increasing the capacity of the cell to produce ATP. While these adaptations might be inextricably linked through regulation of the proliferation-differentiation process, recent studies have identified a number of transcriptional regulators as AMPK substrates that give insights into the regulation of transcription by AMPK in a number of metabolically active tissues.
Language eng
Field of Research 060114 Systems Biology
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30025020

Document type: Journal Article
Collection: School of Medicine
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Created: Fri, 12 Mar 2010, 11:02:16 EST by Sean McGee

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