Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans

Burgomaster, Kirsten A., Howarth, Krista R., Phillips, Stuart M., Rakobowchuck, Mark, MacDonald, Maureen J., McGee, Sean L. and Gibala, Martin J. 2008, Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans, Journal of physiology, vol. 586, no. 1, pp. 151-160.

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Title Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans
Author(s) Burgomaster, Kirsten A.
Howarth, Krista R.
Phillips, Stuart M.
Rakobowchuck, Mark
MacDonald, Maureen J.
McGee, Sean L.
Gibala, Martin J.
Journal name Journal of physiology
Volume number 586
Issue number 1
Start page 151
End page 160
Total pages 10
Publisher Wiley-Blackwell
Place of publication Oxford, England
Publication date 2008-01-01
ISSN 0022-3751
1469-7793
Summary Low-volume ‘sprint’ interval training (SIT) stimulates rapid improvements in muscle oxidative capacity that are comparable to levels reached following traditional endurance training (ET) but no study has examined metabolic adaptations during exercise after these different training strategies. We hypothesized that SIT and ET would induce similar adaptations in markers of skeletal muscle carbohydrate (CHO) and lipid metabolism and metabolic control during exercise despite large differences in training volume and time commitment. Active but untrained subjects (23 ± 1 years) performed a constant-load cycling challenge (1 h at 65% of peak oxygen uptake before and after 6 weeks of either SIT or ET (n = 5 men and 5 women per group). SIT consisted of four to six repeats of a 30 s ‘all out’ Wingate Test (mean power output ∼500 W) with 4.5 min recovery between repeats, 3 days per week. ET consisted of 40–60 min of continuous cycling at a workload that elicited ∼65% (mean power output ∼150 W) per day, 5 days per week. Weekly time commitment (∼1.5 versus ∼4.5 h) and total training volume (∼225 versus ∼2250 kJ week−1) were substantially lower in SIT versus ET. Despite these differences, both protocols induced similar increases (P < 0.05) in mitochondrial markers for skeletal muscle CHO (pyruvate dehydrogenase E1α protein content) and lipid oxidation (3-hydroxyacyl CoA dehydrogenase maximal activity) and protein content of peroxisome proliferator-activated receptor-γ coactivator-1α. Glycogen and phosphocreatine utilization during exercise were reduced after training, and calculated rates of whole-body CHO and lipid oxidation were decreased and increased, respectively, with no differences between groups (all main effects, P < 0.05). Given the markedly lower training volume in the SIT group, these data suggest that high-intensity interval training is a time-efficient strategy to increase skeletal muscle oxidative capacity and induce specific metabolic adaptations during exercise that are comparable to traditional ET.
Language eng
Field of Research 060114 Systems Biology
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30025023

Document type: Journal Article
Collection: School of Medicine
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