Optimizing training adaptations by manipulating glycogen

Baar, Keith and McGee, Sean L. 2008, Optimizing training adaptations by manipulating glycogen, European journal of sport science, vol. 8, no. 2, pp. 97-106.

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Title Optimizing training adaptations by manipulating glycogen
Author(s) Baar, Keith
McGee, Sean L.
Journal name European journal of sport science
Volume number 8
Issue number 2
Start page 97
End page 106
Total pages 10
Publisher Taylor & Francis
Place of publication Abingdon, England
Publication date 2008-03
ISSN 1746-1391
1536-7290
Summary For decades, glycogen has been recognized as a storage form of glucose within the liver and muscles. Only recently has a greater role for glycogen as a regulator of metabolic signalling been suggested. Glycogen either directly or indirectly regulates a number of signalling proteins, including the adenosine-5'-phosphate- (AMP-) activated protein kinase (AMPK) and p38 mitogen-activated protein kinase (MAPK). AMPK and p38 MAPK play a significant role in controlling the expression and activity of the peroxisome proliferator activated receptor γ coactivators (PGCs), respectively. The PGCs can directly increase muscle mitochondrial mass and endurance exercise performance. As low muscle glycogen is generally associated with greater activation of these pathways, the concept of training with low glycogen to maximize the physiological adaptations to endurance exercise is gaining acceptance in the scientific community. In this review, we evaluate the scientific basis for this philosophy and propose some practical applications of this philosophy for the general population as well as elite endurance athletes.
Language eng
Field of Research 060114 Systems Biology
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, European College of Sport Science/Taylor and Francis
Persistent URL http://hdl.handle.net/10536/DRO/DU:30025029

Document type: Journal Article
Collections: School of Medicine
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Created: Fri, 12 Mar 2010, 11:44:03 EST by Sean McGee

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