Comparative structural analyses of purified glycogen particles from rat liver, human skeletal muscle and commercial preparations

Ryu, Je-Hoon, Drain, Jace, Kim, Jung Hwan, McGee, Sean L., Gray-Weale, Angus, Waddington, Lynne, Parker, Glendon J., Hargreaves, Mark, Yoo, Sang-Ho and Stapleton, David 2009, Comparative structural analyses of purified glycogen particles from rat liver, human skeletal muscle and commercial preparations, International journal of biological macromolecules, vol. 45, no. 5, pp. 478-482.

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Title Comparative structural analyses of purified glycogen particles from rat liver, human skeletal muscle and commercial preparations
Author(s) Ryu, Je-Hoon
Drain, Jace
Kim, Jung Hwan
McGee, Sean L.
Gray-Weale, Angus
Waddington, Lynne
Parker, Glendon J.
Hargreaves, Mark
Yoo, Sang-Ho
Stapleton, David
Journal name International journal of biological macromolecules
Volume number 45
Issue number 5
Start page 478
End page 482
Total pages 5
Publisher Elsevier BV
Place of publication Amsterdam, Netherlands
Publication date 2009-12-01
ISSN 0141-8130
1879-0003
Summary Glycogen is a cellular energy store that is crucial for whole body energy metabolism, metabolic regulation and exercise performance. To understand glycogen structure we have purified glycogen particles from rat liver and human skeletal muscle tissues and compared their biophysical properties with those found in commercial glycogen preparations. Ultrastructural analysis of commercial liver glycogens fails to reveal the classical α-rosette structure but small irregularly shaped particles. In contrast, commercial slipper limpet glycogen consists of β-particles with similar branching and chain lengths to purified rat liver glycogen together with a tendency to form small α-particles, and suggest it should be used as a source of glycogen for all future studies requiring a substitute for mammalian liver glycogen.
Language eng
Field of Research 060112 Structural Biology (incl Macromolecular Modelling)
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2009, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30025034

Document type: Journal Article
Collection: School of Medicine
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