AMPK-mediated transcription in skeletal muscle

McGee, Sean L. and Hargreaves, Mark 2010, AMPK-mediated transcription in skeletal muscle, Clinical science, vol. 118, no. 8, pp. 507-518.

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Title AMPK-mediated transcription in skeletal muscle
Author(s) McGee, Sean L.
Hargreaves, Mark
Journal name Clinical science
Volume number 118
Issue number 8
Start page 507
End page 518
Total pages 12
Publisher Portland Press
Place of publication London, England
Publication date 2010-01-26
ISSN 0143-5221
1470-8736
Summary Skeletal muscle phenotype plays a critical role in human performance and health, and skeletal muscle oxidative capacity is a key determinant of exercise tolerance. More recently, defective muscle oxidative metabolism has been implicated in a number of conditions associated with the metabolic syndrome, cardiovascular disease and muscle-wasting disorders. AMPK (AMP-activated protein kinase) is a critical regulator of cellular and organismal energy balance. AMPK has also emerged as a key regulator of skeletal muscle oxidative function, including metabolic enzyme expression, mitochondrial biogenesis and angiogenesis. AMPK mediates these processes primarily through alterations in gene expression. The present review examines the role of AMPK in skeletal muscle transcription and provides an overview of the known transcriptional substrates mediating the effects of AMPK on skeletal muscle phenotype.
Language eng
Field of Research 060114 Systems Biology
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2010
Copyright notice ©2010, Portland Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30025038

Document type: Journal Article
Collection: School of Medicine
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Created: Fri, 12 Mar 2010, 12:07:42 EST by Sean McGee

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