Genetic and environmental influences on variation in balance performance among female twin pairs aged 21-82 years

El Haber, Natalie, Hill, Keith D., Cassano, Anne-Marie T., Paton, Lynda M., MacInnis, Robert J., Cui, James S., Hopper, John L. and Wark, John D. 2006, Genetic and environmental influences on variation in balance performance among female twin pairs aged 21-82 years, American journal of epidemiology, vol. 164, no. 3, pp. 246-256.

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Title Genetic and environmental influences on variation in balance performance among female twin pairs aged 21-82 years
Author(s) El Haber, Natalie
Hill, Keith D.
Cassano, Anne-Marie T.
Paton, Lynda M.
MacInnis, Robert J.
Cui, James S.
Hopper, John L.
Wark, John D.
Journal name American journal of epidemiology
Volume number 164
Issue number 3
Start page 246
End page 256
Total pages 11
Publisher Oxfod University Press
Place of publication Cary, N.C.
Publication date 2006
ISSN 0002-9262
1476-6256
Keyword(s) Adult
Age Factors
Aged
Aged, 80 and over
Environment
Female
Genetic Variation
Health Status
Humans
Linear Models
Middle Aged
Postural Balance
Principal Component Analysis
Psychomotor Performance
Twins/genetics
Twins, Dizygotic
Twins, Monozygotic
Victoria
Summary Genetic and environmental influences on variation in balance performance were measured in 93 monozygous and 83 dizygous female twin pairs aged 21–82 years (mean age, 50.5 years) in Melbourne, Australia, between 1999 and 2003. The authors administered clinical (Lord's Balance Test and Step Test) and laboratory tests of static and dynamic balance from the Chattecx Balance System with and without distractor tasks. The authors conducted factor analysis and estimated genetic and environmental variance components and heritability (defined as additive genetic variance as a proportion of all variance, after adjustment for age) using a multivariate normal model with the statistical package FISHER. Three factors were identified and adjusted for age. Heritability was 46% (standard error (SE), 9) for the "sensory balance tests" factor and 30% (SE, 9) for the "static and dynamic perturbations" factor. For both factors, the remaining variance was attributed to unique environmental effects. There was no evidence that genetic factors influenced variation in the "dynamic weight shift tests" factor, with environmental effects shared by twins accounting for 38% (SE, 7) of variance. Neither genetic nor environmental proportions of variance differed significantly between twin subgroups by age (≤50/>50 years). An age-related decline in performance measures was found across the whole sample. These results imply that balance impairments may have a heritable element.
Language eng
Field of Research 111706 Epidemiology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, the Johns Hopkins Bloomberg School of Public Health
Persistent URL http://hdl.handle.net/10536/DRO/DU:30025315

Document type: Journal Article
Collection: Public Health Research, Evaluation, and Policy Cluster
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