Familial and genomic analyses of postural changes in systolic and diastolic blood pressure

Harrap, S. B., Cui, J. S., Wong, Z. Y. and Hopper, J. L. 2004, Familial and genomic analyses of postural changes in systolic and diastolic blood pressure, Hypertension, vol. 43, no. 3, pp. 586-591.


Title Familial and genomic analyses of postural changes in systolic and diastolic blood pressure
Author(s) Harrap, S. B.
Cui, J. S.
Wong, Z. Y.
Hopper, J. L.
Journal name Hypertension
Volume number 43
Issue number 3
Start page 586
End page 591
Total pages 6
Publisher Lippincott Williams & Wilkins
Place of publication Philadelphia, Pa.
Publication date 2004
ISSN 1524-4563
Keyword(s) Adult
Aged
Blood Pressure/genetics
Diastole/genetics
Female
Genome, Human
Humans
Linkage (Genetics)
Male
Middle Aged
Nuclear Family
Phenotype
Posture
Quantitative Trait Loci
Systole/genetics
Summary The physiological adaptation to the erect posture involves integrated neural and cardiovascular responses that might be determined by genetic factors. We examined the familial- and individual-specific components of variance for postural changes in systolic and diastolic blood pressure in 767 volunteer nuclear adult families from the Victorian Family Heart Study. In 274 adult sibling pairs, we made a genome-wide scan using 400 markers for quantitative trait loci linked with the postural changes in systolic and diastolic pressures. Overall, systolic pressure did not change on standing, but there was considerable variation in this phenotype (SD=8.1 mm Hg). Familial analyses revealed that 25% of the variance of change in systolic pressure was attributable to genetic factors. In contrast, diastolic pressure increased by 6.3 mm Hg (SD=7.0 mm Hg) on standing and there was no evidence of contributory genetic factors. Multipoint quantitative genome linkage mapping suggested evidence (Z=3.2) of linkage of the postural change in systolic pressure to chromosome 12 but found no genome-wide evidence of linkage for the change in diastolic pressure. These findings suggest that genetic factors determine whether systolic pressure decreases or increases when one stands, possibly as the result of unidentified alleles on chromosome 12. The genetics of postural changes in systolic blood pressure might reflect the general buffering function of the baroreflex; thereby, the predisposition to sudden decreases or increases in systolic pressure might cause postural hypotension or vessel wall disruption, respectively.
Language eng
Field of Research 029903 Medical Physics
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2004, American Heart Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30025321

Document type: Journal Article
Collection: Public Health Research, Evaluation, and Policy Cluster
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