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Plasmodium falciparum induces reorganization of host membrane proteins during intraerythrocytic growth

Parker, Phillip D., Tilley, Leanne and Klonis, Nectarios 2004, Plasmodium falciparum induces reorganization of host membrane proteins during intraerythrocytic growth, Blood, vol. 103, no. 6, pp. 2404-2406, doi: 10.1182/blood-2003-08-2692.

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Title Plasmodium falciparum induces reorganization of host membrane proteins during intraerythrocytic growth
Formatted title Plasmodium falciparum induces reorganization of host membrane proteins
during intraerythrocytic growth
Author(s) Parker, Phillip D.
Tilley, Leanne
Klonis, Nectarios
Journal name Blood
Volume number 103
Issue number 6
Start page 2404
End page 2406
Publisher American Society of Hematology
Place of publication Washington D.C.
Publication date 2004-03-15
ISSN 0006-4971
1528-0020
Summary The virulence of the malaria parasite, Plasmodium falciparum, is due in large part to the way in which it modifies the membrane of its erythrocyte host. In this work we have used confocal microscopy and fluorescence recovery after photo-bleaching to examine the lateral mobility of host membrane proteins in erythrocytes infected with P falciparum at different stages of parasite growth. The erythrocyte membrane proteins band 3 and glycophorin show a marked decrease in mobility during the trophozoite stage of growth. Erythrocytes infected with a parasite strain that does not express the knob-associated histidine-rich protein show similar effects, indicating that this parasite protein does not contribute to the immobilization of the host proteins. Erythrocytes infected with ring-stage parasites exhibit intermediate mobility indicating that the parasite is able to modify its host prior to its active feeding stage.
Language eng
DOI 10.1182/blood-2003-08-2692
Field of Research 110106 Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2004, The American Society of Hematology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30025537

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Created: Mon, 22 Mar 2010, 15:29:50 EST by Gabrielle Lamb

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