In vitro cytotoxicity of binary TI alloys for bone implants

Li, Yuncang, Wong, Cynthia, Xiong, Jianyu, Hodgson, Peter and Wen, Cui`e 2009, In vitro cytotoxicity of binary TI alloys for bone implants, Materials science forum, vol. 618-619, pp. 295-298, doi: 10.4028/

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Title In vitro cytotoxicity of binary TI alloys for bone implants
Author(s) Li, Yuncang
Wong, Cynthia
Xiong, Jianyu
Hodgson, Peter
Wen, Cui`e
Journal name Materials science forum
Volume number 618-619
Start page 295
End page 298
Total pages 4
Publisher Trans Tech
Place of publication Stafa-Zurich, Switzerland
Publication date 2009-04
ISSN 0255-5476
Keyword(s) binary Ti alloy
SaOS-2 cell
Summary Interest in using titanium (Ti) alloys as load-bearing implant materials has increased due to their high strength to weight ratio, lower elastic modulus, and superior biocompatibility and enhanced corrosion resistance compared to conventional metals such as stainless steel and Co-Cr alloys. In the present study, the in vitro cytotoxicity of five binary titanium alloys, Ti15Ta, Ti15Nb, Ti15Zr, Ti15Sn and Ti15Mo, was assessed using human osteosarcoma cell line, SaOS-2 cells. The Cell proliferation and viability were determined, and cell adhesion and morphology on the surfaces of the binary Ti alloys after cell culture were observed by SEM. Results indicated that the Ti binary alloys of Ti15Ta, Ti15Nb and Ti15Zr exhibited the same level of excellent biocompatibility; Ti15Sn alloy exhibited a moderate biocompatibility while Ti15Mo alloy exhibited a moderate cytotoxicity. The SaOS-2 osteoblast-like cells had flattened and spread across the surfaces of the Ti15Ta, Ti15Nb, Ti15Zr and Ti15Sn groups; however, the cell shapes on the Ti15Mo alloy was shrinking and unhealthy. These results indicated that the Mo contents should be limited to a certain level in the design and development of new Ti alloys for implant material applications.
Language eng
DOI 10.4028/
Field of Research 090301 Biomaterials
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
HERDC collection year 2009
Copyright notice ©2009, Trans Tech Publications
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Document type: Journal Article
Collections: Centre for Material and Fibre Innovation
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