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Ti6Ta4Sn alloy and subsequent scaffolding for bone tissue engineering

Li, Yuncang, Xiong, Jianyu, Wong, Cynthia S., Hodgson, Peter D. and Wen, Cui'e 2009, Ti6Ta4Sn alloy and subsequent scaffolding for bone tissue engineering, Tissue engineering part A, vol. 15, no. 10, pp. 3151-3159.

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Title Ti6Ta4Sn alloy and subsequent scaffolding for bone tissue engineering
Author(s) Li, Yuncang
Xiong, Jianyu
Wong, Cynthia S.
Hodgson, Peter D.
Wen, Cui'e
Journal name Tissue engineering part A
Volume number 15
Issue number 10
Start page 3151
End page 3159
Total pages 9
Publisher Mary Ann Liebert Publishers
Place of publication Rochelle, N.Y.
Publication date 2009
ISSN 1937-3341
Keyword(s) Titanium
Binary Ti Alloys
SaOS-2 cells
Biocompatibility
Summary Porous titanium (Ti) and titanium alloys are promising scaffold biomaterials for bone tissue engineering, because they have the potential to provide new bone tissue ingrowth abilities and low elastic modulus to match that of
natural bone. In the present study, a new highly porous Ti6Ta4Sn alloy scaffold with the addition of biocompatible alloying elements (tantalum (Ta) and tin (Sn)) was prepared using a space-holder sintering method. The
strength of the Ti6Ta4Sn scaffold with a porosity of 75% was found to be significantly higher than that of a pure Ti scaffold with the same porosity. The elastic modulus of the porous alloy can be customized to match that of
human bone by adjusting its porosity. In addition, the porous Ti6Ta4Sn alloy exhibited an interconnected porous structure, which enabled the ingrowth of new bone tissues. Cell culture results revealed that human SaOS2
osteoblast-like cells grew and spread well on the surfaces of the solid alloy, and throughout the porous scaffold. The surface roughness of the alloy showed a significant effect on the cell behavior, and the optimum surface
roughness range for the adhesion of the SaOS2 cell on the alloy was 0.15 to 0.35 mm. The present study illustrated the feasibility of using the porous Ti6Ta4Sn alloy scaffold as an orthopedic implant material with a special
emphasis on its excellent biomechanical properties and in vitro biocompatibility with a high preference by osteoblast-like cells.
Language eng
Field of Research 091207 Metals and Alloy Materials
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2009, Mary Ann Liebert Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30025568

Document type: Journal Article
Collections: Centre for Material and Fibre Innovation
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