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Characterization of a conserved rhoptry-associated leucine zipper-like protein in the malaria parasite Plasmodium falciparum

Haase, Silvia, Cabrera, Ana, Langer, Christine, Treeck, Moritz, Struck, Nicole, Herrmann, Susann, Jansen, Pascal W., Bruchhaus, Iris, Bachmann, Anna, Dias, Suzana, Cowman, Alan F., Stunnenberg, Hendrik G., Spielmann, Tobias and Gilberger, Tim-Wolf 2008, Characterization of a conserved rhoptry-associated leucine zipper-like protein in the malaria parasite Plasmodium falciparum, Infection and immunity, vol. 76, no. 3, pp. 879-887, doi: 10.1128/IAI.00144-07.

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Title Characterization of a conserved rhoptry-associated leucine zipper-like protein in the malaria parasite Plasmodium falciparum
Author(s) Haase, Silvia
Cabrera, Ana
Langer, Christine
Treeck, Moritz
Struck, Nicole
Herrmann, Susann
Jansen, Pascal W.
Bruchhaus, Iris
Bachmann, Anna
Dias, Suzana
Cowman, Alan F.
Stunnenberg, Hendrik G.
Spielmann, Tobias
Gilberger, Tim-Wolf
Journal name Infection and immunity
Volume number 76
Issue number 3
Start page 879
End page 887
Total pages 9
Publisher American Society for Microbiology
Place of publication Washington, D.C.
Publication date 2008-03
ISSN 0019-9567
1098-5522
Keyword(s) malaria
Summary One of the key processes in the pathobiology of the malaria parasite is the invasion and subsequent modification of the human erythrocyte. In this complex process, an unknown number of parasite proteins are involved, some of which are leading vaccine candidates. The majority of the proteins that play pivotal roles in invasion are either stored in the apical secretory organelles or located on the surface of the merozoite, the invasive stage of the parasite. Using transcriptional and structural features of these known proteins, we performed a genomewide search that identified 49 hypothetical proteins with a high probability of being located on the surface of the merozoite or in the secretory organelles. Of these candidates, we characterized a novel leucine zipper-like protein in Plasmodium falciparum that is conserved in Plasmodium spp. This protein is expressed in late blood stages and localizes to the rhoptries of the parasite. We demonstrate that this Plasmodium sp.-specific protein has a high degree of conservation within field isolates and that it is refractory to gene knockout attempts and thus might play an important role in invasion.
Language eng
DOI 10.1128/IAI.00144-07
Field of Research 110803 Medical Parasitology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, American Society for Microbiology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30025964

Document type: Journal Article
Collection: School of Medicine
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