Electrospinning of nanofibres for construction of vital organ replacements

Owida, Amal, Mo, Xiu Mei, Wong, Cynthia S. and Morsi, Yos S. 2006, Electrospinning of nanofibres for construction of vital organ replacements, in ICONN 2006 : International Conference on Nanoscience and Nanotechnology, 3-7 July 2006, Brisbane, Queensland, Australia, ARCNN, Canberra, A.C.T., pp. 585-587.

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Title Electrospinning of nanofibres for construction of vital organ replacements
Author(s) Owida, Amal
Mo, Xiu Mei
Wong, Cynthia S.
Morsi, Yos S.
Conference name International Conference on Nanoscience and Nanotechnology (2006 : Brisbane, Queensland)
Conference location Brisbane, Queensland
Conference dates 3-7 July 2006
Title of proceedings ICONN 2006 : International Conference on Nanoscience and Nanotechnology, 3-7 July 2006, Brisbane, Queensland, Australia
Editor(s) [Unknown]
Publication date 2006
Conference series International Conference on Nanoscience and Nanotechnology
Start page 585
End page 587
Publisher ARCNN
Place of publication Canberra, A.C.T.
Summary This paper described the production of a novel biosynthetic material using the manufacturing technique of electro spinning for the construction of scaffold for organ replacement. This electrostatic technique uses an electric field to control the deposition of polymer fibres onto a specific substrate to fabricate fibrous polymer constructs composed of fibre diameters ranging from several microns down to 100 nm or less. Two areas of research, in particular, heart valve leaflets and blood vessel will be discussed. Here, a sandwich structure nanofibre mesh was used to construct materials for leaflets of heart valve and blood vessel. In the case of heart valve leaflet, the randomly oriented polyurethane nanofibres were prepared as the first layer, followed by gelatin-chitosan complex layer. Complex nanofibres were initially used to spin on the PU layer with cross orientation to mimic the fibrosa layer. A gelatin and chitosan complex was then spun onto the other side of PU nanofibre mesh to mimic the ventricularis layer. This particular sandwich structure using the PU layer was designed to simulate the mechanical properties of natural tissue. In addition, this design was aimed to provide good biocompatibility and improved cellular environment to assist in adhesion and proliferation. Smooth muscle cells adhered and flattened out onto the surface of the gelatin-chitosan complex as early as 1 day post seeding. There is great potential for this biosynthetic biocompatible nanofibrous material to be developed for various clinical applications.
Language eng
Field of Research 100703 Nanobiotechnology
HERDC Research category E1.1 Full written paper - refereed
Copyright notice ©2006, IEEE
Persistent URL http://hdl.handle.net/10536/DRO/DU:30026046

Document type: Conference Paper
Collection: Centre for Material and Fibre Innovation
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