Endothelialisation and cell retention on gelation-chitosan coated electrospun polyurethane, poly (lactide-co-glycolide) and collagen-coated pericardium

Patel, Shital, Wong, Cynthia, Morsi, Yos S., Mo,Xiu Mei and Rui, Chen 2008, Endothelialisation and cell retention on gelation-chitosan coated electrospun polyurethane, poly (lactide-co-glycolide) and collagen-coated pericardium, in FMST 2008 : Papers presented at the International Conference on Frontiers in Materials Science & Technology, Trans Tech Publications, Zug, Switzerland, pp. 233-236.

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Title Endothelialisation and cell retention on gelation-chitosan coated electrospun polyurethane, poly (lactide-co-glycolide) and collagen-coated pericardium
Author(s) Patel, Shital
Wong, Cynthia
Morsi, Yos S.
Mo,Xiu Mei
Rui, Chen
Conference name International Conference on Frontiers in Materials Science & Technology (2008 : Brisbane, Qld.)
Conference location Brisbane, Qld.
Conference dates 26-28 Mar. 2008
Title of proceedings FMST 2008 : Papers presented at the International Conference on Frontiers in Materials Science & Technology
Editor(s) [Unknown]
Publication date 2008
Series Advanced materials research; v.32
Conference series Frontiers in Materials Science and Technology Conference
Start page 233
End page 236
Publisher Trans Tech Publications
Place of publication Zug, Switzerland
Keyword(s) Endothelial cells
Cell retention
Electrospun polyurethane (PU)
Poly (lactide-coglycolide) (PGA/PLA)
Collagen-coated pericardium
Summary Arterial bypass and heart valve replacements are two of the most common surgical treatments in cardiovascular surgery today. Currently, artificial materials are used as substitute for these cardiac tissues. However, these foreign materials do not have the ability to grow, repair or remodel and are thrombogenic, leading to stenosis. With the aid of tissue engineering, it is possible to develop functional identical copies of healthy heart valves and arteries, which are biocompatible. Although much effort has been made into this area, there are still inconsistencies with respect to
endothelialisation and cell retention on synthetic biological grafts. These variations may be attributed to differences in factors such as cell seeding density, incubation periods and effects of shear stress. In this study, we have compared the endothelialisation and cell retention between gelain chitosan-coated electrospun polyurethane (PU), poly (lactide co-glycolide) (PGA/PLA) and collagen-coated pericardium. Endothelial cells adhered to all of the materials as early as 1–day post seeding. After 7-day of seeding, the coverage on PU was almost 45% and that on PGA/PLA was about 25% and the least was on collagen-coated pericardium of approximately 15%. It was observed that the PU showed superior cell coverage and cell retention in comparison to the PGA/PLA and collagen-coated pericardium.
ISSN 1662-8985
Language eng
Field of Research 090301 Biomaterials
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category E1.1 Full written paper - refereed
Copyright notice ©2008, Trans Tech Publications, Switzerland
Persistent URL http://hdl.handle.net/10536/DRO/DU:30026047

Document type: Conference Paper
Collection: Centre for Material and Fibre Innovation
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