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Computational thermal analysis of a continuous flow micro Polymerase Chain Reaction (PCR) chip

Sugumar, D., Ashraf, M. A. and Kong, L. X. 2006, Computational thermal analysis of a continuous flow micro Polymerase Chain Reaction (PCR) chip, in SPIE 2006 : Proceedings : Micro and Nanotechnology : Materials, Processes, Packaging, and Systems III, SPIE, International Society for Optical Engineering, Bellingham, Wash..

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Title Computational thermal analysis of a continuous flow micro Polymerase Chain Reaction (PCR) chip
Author(s) Sugumar, D.
Ashraf, M. A.
Kong, L. X.
Conference name International Society for Optical Engineering (2006 : Adelaide, S.Aust.)
Conference location Adelaide, S. Aust.
Conference dates 1-13 December 2006
Title of proceedings SPIE 2006 : Proceedings : Micro and Nanotechnology : Materials, Processes, Packaging, and Systems III
Editor(s) Chiao, Jung-Chih
Dzurak, Andrew S.
Jagadish, Chennupati
Thiel, David V.
Publication date 2006
Conference series International Society for Optical Engineering Conference
Publisher SPIE, International Society for Optical Engineering
Place of publication Bellingham, Wash.
Keyword(s) PCR
thermal heating
microchannel
MEMS
Microfluidic
Summary The first continuous flow micro PCR introduced in 1998 has attracted considerable attention for the past several years because of its ability to amplify DNA at much faster rate than the conventional PCR and micro chamber PCR method. The amplification is obtained by moving the sample through 3 different fixed temperature zones. In this paper, the thermal behavior of a continuous flow PCR chip is studied using commercially available finite element software. We study the temperature uniformity and temperature gradient on the chip’s top surface, the cover plate and the interface of the two layers. The material for the chip body and cover plate is glass. The duration for the PCR chip to achieve equilibrium temperature is also studied.
ISBN 9780819465238
0819465232
Language eng
Field of Research 091299 Materials Engineering not elsewhere classified
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category E1.1 Full written paper - refereed
Persistent URL http://hdl.handle.net/10536/DRO/DU:30026064

Document type: Conference Paper
Collection: Centre for Material and Fibre Innovation
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